Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible
We present the first, to our knowledge, case of a dedifferentiated low-grade central osteosarcoma (LCOS) of the mandible. A 48-year-old Japanese woman underwent enucleation under general anesthesia after a diagnosis of ossifying fibroma. At the second recurrence, the pathological diagnosis after bio...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2022/9321728 |
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| _version_ | 1832567917702545408 |
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| author | Kenji Yamagata Naomi Ishibashi-Kanno Ryota Matsuoka Fumihiko Uchida Satoshi Fukuzawa Hiroki Bukawa |
| author_facet | Kenji Yamagata Naomi Ishibashi-Kanno Ryota Matsuoka Fumihiko Uchida Satoshi Fukuzawa Hiroki Bukawa |
| author_sort | Kenji Yamagata |
| collection | DOAJ |
| description | We present the first, to our knowledge, case of a dedifferentiated low-grade central osteosarcoma (LCOS) of the mandible. A 48-year-old Japanese woman underwent enucleation under general anesthesia after a diagnosis of ossifying fibroma. At the second recurrence, the pathological diagnosis after biopsy was of sarcoma with MDM2(+) and CDK4(+) immunohistochemical staining results. Hemimandibulotomy, supraomohyoid neck dissection, and free-flap reconstruction with a rectus abdominal flap were performed. A retrospective reevaluation of the first specimen with additional immunohistochemical staining for MDM2 and CDK4 yielded a final diagnosis of dedifferentiated LCOS. The patient showed no recurrence or lung metastasis 3 years after the final surgery. |
| format | Article |
| id | doaj-art-1c16d1eb6b20446e80d40fe8d1381b02 |
| institution | Kabale University |
| issn | 2090-6455 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-1c16d1eb6b20446e80d40fe8d1381b022025-02-03T01:00:13ZengWileyCase Reports in Dentistry2090-64552022-01-01202210.1155/2022/9321728Dedifferentiated Low-Grade Central Osteosarcoma of the MandibleKenji Yamagata0Naomi Ishibashi-Kanno1Ryota Matsuoka2Fumihiko Uchida3Satoshi Fukuzawa4Hiroki Bukawa5Department of Oral and Maxillofacial SurgeryDepartment of Oral and Maxillofacial SurgeryDepartment of Diagnostic PathologyDepartment of Oral and Maxillofacial SurgeryDepartment of Oral and Maxillofacial SurgeryDepartment of Oral and Maxillofacial SurgeryWe present the first, to our knowledge, case of a dedifferentiated low-grade central osteosarcoma (LCOS) of the mandible. A 48-year-old Japanese woman underwent enucleation under general anesthesia after a diagnosis of ossifying fibroma. At the second recurrence, the pathological diagnosis after biopsy was of sarcoma with MDM2(+) and CDK4(+) immunohistochemical staining results. Hemimandibulotomy, supraomohyoid neck dissection, and free-flap reconstruction with a rectus abdominal flap were performed. A retrospective reevaluation of the first specimen with additional immunohistochemical staining for MDM2 and CDK4 yielded a final diagnosis of dedifferentiated LCOS. The patient showed no recurrence or lung metastasis 3 years after the final surgery.http://dx.doi.org/10.1155/2022/9321728 |
| spellingShingle | Kenji Yamagata Naomi Ishibashi-Kanno Ryota Matsuoka Fumihiko Uchida Satoshi Fukuzawa Hiroki Bukawa Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible Case Reports in Dentistry |
| title | Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible |
| title_full | Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible |
| title_fullStr | Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible |
| title_full_unstemmed | Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible |
| title_short | Dedifferentiated Low-Grade Central Osteosarcoma of the Mandible |
| title_sort | dedifferentiated low grade central osteosarcoma of the mandible |
| url | http://dx.doi.org/10.1155/2022/9321728 |
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