The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps
We aimed to estimate the impact of ingestion of a pure protein load on the glucose levels in T1DM patients treated with insulin pumps. We examined 10 T1DM patients (6 females, mean age—32.3 years, mean HbA1c—6.8%) treated with insulin pumps equipped with a continuous glucose monitoring system (CGMS)...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/216918 |
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| author | Tomasz Klupa Teresa Benbenek-Klupa Bartlomiej Matejko Sandra Mrozinska Maciej T. Malecki |
| author_facet | Tomasz Klupa Teresa Benbenek-Klupa Bartlomiej Matejko Sandra Mrozinska Maciej T. Malecki |
| author_sort | Tomasz Klupa |
| collection | DOAJ |
| description | We aimed to estimate the impact of ingestion of a pure protein load on the glucose levels in T1DM patients treated with insulin pumps. We examined 10 T1DM patients (6 females, mean age—32.3 years, mean HbA1c—6.8%) treated with insulin pumps equipped with a continuous glucose monitoring system (CGMS). In Phase I, baseline insulin infusion was optimized to minimize the differences in fasting glucose levels to less than 30 mg/dL between any two time points between 9 a.m. and 3 p.m. In Phase II, the patients were exposed to single pure protein load. CGMS record was performed and the glucose pattern was defined for 6 hours of each phase. The maximal glucose level increment was similar for the entire duration of the fasting and the protein load test (26.6 versus 27.6 mg/dL, resp., P<0.78). There was only a borderline difference in change between baseline versus 6th hour glucose (12.5 and 19.0 mg/dL, P=0.04). Glucose variability, assessed by standard deviation of mean glucose levels, was 36.4 and 37.9 mg/dL, respectively (P=0.01). The administration of a pure protein load does not seem to have a clinically significant impact on glucose levels in T1DM patients treated with insulin pumps. |
| format | Article |
| id | doaj-art-1c1517ea1e844e20bb18aa2a78b09bea |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1c1517ea1e844e20bb18aa2a78b09bea2025-02-03T06:00:44ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/216918216918The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin PumpsTomasz Klupa0Teresa Benbenek-Klupa1Bartlomiej Matejko2Sandra Mrozinska3Maciej T. Malecki4Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, PolandDiabWay Enterprise, Krakow, PolandDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, PolandDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, PolandDepartment of Metabolic Diseases, Jagiellonian University Medical College, Krakow, PolandWe aimed to estimate the impact of ingestion of a pure protein load on the glucose levels in T1DM patients treated with insulin pumps. We examined 10 T1DM patients (6 females, mean age—32.3 years, mean HbA1c—6.8%) treated with insulin pumps equipped with a continuous glucose monitoring system (CGMS). In Phase I, baseline insulin infusion was optimized to minimize the differences in fasting glucose levels to less than 30 mg/dL between any two time points between 9 a.m. and 3 p.m. In Phase II, the patients were exposed to single pure protein load. CGMS record was performed and the glucose pattern was defined for 6 hours of each phase. The maximal glucose level increment was similar for the entire duration of the fasting and the protein load test (26.6 versus 27.6 mg/dL, resp., P<0.78). There was only a borderline difference in change between baseline versus 6th hour glucose (12.5 and 19.0 mg/dL, P=0.04). Glucose variability, assessed by standard deviation of mean glucose levels, was 36.4 and 37.9 mg/dL, respectively (P=0.01). The administration of a pure protein load does not seem to have a clinically significant impact on glucose levels in T1DM patients treated with insulin pumps.http://dx.doi.org/10.1155/2015/216918 |
| spellingShingle | Tomasz Klupa Teresa Benbenek-Klupa Bartlomiej Matejko Sandra Mrozinska Maciej T. Malecki The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps International Journal of Endocrinology |
| title | The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps |
| title_full | The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps |
| title_fullStr | The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps |
| title_full_unstemmed | The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps |
| title_short | The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps |
| title_sort | impact of a pure protein load on the glucose levels in type 1 diabetes patients treated with insulin pumps |
| url | http://dx.doi.org/10.1155/2015/216918 |
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