AKR1C1 protects against intracerebral hemorrhage by suppressing neuronal cell death via the P53/SLC7A11/GPX4 axis

AKR1C1 protects against intracerebral hemorrhage by suppressing neuronal cell death via the P53/SLC7A11/GPX4 axis

Intracerebral hemorrhage (ICH) is associated with the highest rates of mortality and residual disability. To date, effective treatments to delay or prevent ICH are still lacking. Multiple forms of neuronal cell death have been discovered following ICH, including apoptosis, necrosis, autophagy, and f...

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Bibliographic Details
Main Authors: Qiyu Yang, Chunyan Wang, Jingwei Cao, Zhanbin Tang, Shurong Duan
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Brain Research Bulletin
Subjects:
Intracerebral hemorrhage
Neuronal cell death
AKR1C1
Ferroptosis
P53/SLC7A11/GPX4 axis
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025000668
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