Validation of histopathology foundation models through whole slide image retrieval
Abstract We evaluated several foundation models in histopathology for image retrieval using a zero-shot approach. These models generated embeddings that were directly employed for retrieval without additional fine-tuning. Our experiments were conducted on diagnostic slides from The Cancer Genome Atl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-88545-9 |
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| Summary: | Abstract We evaluated several foundation models in histopathology for image retrieval using a zero-shot approach. These models generated embeddings that were directly employed for retrieval without additional fine-tuning. Our experiments were conducted on diagnostic slides from The Cancer Genome Atlas (TCGA), which covers 23 organs and 117 cancer subtypes. We used Yottixel as the framework for whole-slide image (WSI) retrieval via patch-based embeddings. Retrieval performance was evaluated using macro-averaged F1 scores for top-1, top-3, and top-5 retrievals. The top-5 retrieval F1 scores indicated varying levels of performance: Yottixel-DenseNet (27% ± 13%), Yottixel-UNI (42% ± 14%), Yottixel-Virchow (40% ± 13%), Yottixel-GigaPath (41% ± 13%), and GigaPath WSI (40% ± 14%). These results demonstrate the potential and limitations of foundation models for histopathology image retrieval, underscoring the need for further advancements in embedding and retrieval techniques. |
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| ISSN: | 2045-2322 |