The impact of aging on neutrophil functions and the contribution to periodontitis
Abstract The increasing aging population and aging-associated diseases have become a global issue for decades. People over 65 show an increased prevalence and greater severity of periodontitis, which poses threats to overall health. Studies have demonstrated a significant association between aging a...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-024-00332-w |
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| author | Zi Wang Anish Saxena Wenbo Yan Silvia M. Uriarte Rafael Siqueira Xin Li |
| author_facet | Zi Wang Anish Saxena Wenbo Yan Silvia M. Uriarte Rafael Siqueira Xin Li |
| author_sort | Zi Wang |
| collection | DOAJ |
| description | Abstract The increasing aging population and aging-associated diseases have become a global issue for decades. People over 65 show an increased prevalence and greater severity of periodontitis, which poses threats to overall health. Studies have demonstrated a significant association between aging and the dysfunction of neutrophils, critical cells in the early stages of periodontitis, and their crosstalk with macrophages and T and B lymphocytes to establish the periodontal lesion. Neutrophils differentiate and mature in the bone marrow before entering the circulation; during an infection, they are recruited to infected tissues guided by the signal from chemokines and cytokines to eliminate invading pathogens. Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues. The impacts of aging on neutrophils’ chemotaxis, anti-microbial function, cell activation, and lifespan result in impaired neutrophil functions and excessive neutrophil activation, which could influence periodontitis course. We summarize the roles of neutrophils in periodontal diseases and the aging-related impacts on neutrophil functional responses. We also explore the underlying mechanisms that can contribute to periodontitis manifestation in aging. This review could help us better understand the pathogenesis of periodontitis, which could offer novel therapeutic targets for periodontitis. |
| format | Article |
| id | doaj-art-1bed7d92fc5148129dd236eb92ee87ee |
| institution | Kabale University |
| issn | 2049-3169 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj-art-1bed7d92fc5148129dd236eb92ee87ee2025-01-19T12:12:31ZengNature Publishing GroupInternational Journal of Oral Science2049-31692025-01-0117111210.1038/s41368-024-00332-wThe impact of aging on neutrophil functions and the contribution to periodontitisZi Wang0Anish Saxena1Wenbo Yan2Silvia M. Uriarte3Rafael Siqueira4Xin Li5Department of Plastic Surgery, Maxillofacial & Oral Health, University of Virginia School of MedicineMolecular Pathobiology Department, New York University College of DentistryDepartment of Plastic Surgery, Maxillofacial & Oral Health, University of Virginia School of MedicineDepartment of Oral Immunology and Infectious Diseases, University of LouisvilleDepartment of Periodontics, Virginia Commonwealth University School of DentistryDepartment of Plastic Surgery, Maxillofacial & Oral Health, University of Virginia School of MedicineAbstract The increasing aging population and aging-associated diseases have become a global issue for decades. People over 65 show an increased prevalence and greater severity of periodontitis, which poses threats to overall health. Studies have demonstrated a significant association between aging and the dysfunction of neutrophils, critical cells in the early stages of periodontitis, and their crosstalk with macrophages and T and B lymphocytes to establish the periodontal lesion. Neutrophils differentiate and mature in the bone marrow before entering the circulation; during an infection, they are recruited to infected tissues guided by the signal from chemokines and cytokines to eliminate invading pathogens. Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues. The impacts of aging on neutrophils’ chemotaxis, anti-microbial function, cell activation, and lifespan result in impaired neutrophil functions and excessive neutrophil activation, which could influence periodontitis course. We summarize the roles of neutrophils in periodontal diseases and the aging-related impacts on neutrophil functional responses. We also explore the underlying mechanisms that can contribute to periodontitis manifestation in aging. This review could help us better understand the pathogenesis of periodontitis, which could offer novel therapeutic targets for periodontitis.https://doi.org/10.1038/s41368-024-00332-w |
| spellingShingle | Zi Wang Anish Saxena Wenbo Yan Silvia M. Uriarte Rafael Siqueira Xin Li The impact of aging on neutrophil functions and the contribution to periodontitis International Journal of Oral Science |
| title | The impact of aging on neutrophil functions and the contribution to periodontitis |
| title_full | The impact of aging on neutrophil functions and the contribution to periodontitis |
| title_fullStr | The impact of aging on neutrophil functions and the contribution to periodontitis |
| title_full_unstemmed | The impact of aging on neutrophil functions and the contribution to periodontitis |
| title_short | The impact of aging on neutrophil functions and the contribution to periodontitis |
| title_sort | impact of aging on neutrophil functions and the contribution to periodontitis |
| url | https://doi.org/10.1038/s41368-024-00332-w |
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