Loss and Dysregulation of Th17 Cells during HIV Infection
Bacterial translocation across the damaged mucosal epithelium has emerged as a major paradigm for chronic immune activation observed during HIV infection. T helper 17 (Th17) cells are a unique lineage of T helper cells that are enriched in mucosal tissues and are thought to play a central role in pr...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/852418 |
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| _version_ | 1832552897835958272 |
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| author | Sandra L. Bixler Joseph J. Mattapallil |
| author_facet | Sandra L. Bixler Joseph J. Mattapallil |
| author_sort | Sandra L. Bixler |
| collection | DOAJ |
| description | Bacterial translocation across the damaged mucosal epithelium has emerged as a major paradigm for chronic immune activation observed during HIV infection. T helper 17 (Th17) cells are a unique lineage of T helper cells that are enriched in mucosal tissues and are thought to play a central role in protecting the integrity of the mucosal barrier and maintaining immune homeostasis at mucosal sites. Th17 cells are lost very early during the course of HIV infection, and their loss has been shown to correlate with bacterial translocation. Interestingly, Th17 cells are unable to completely recover from the early destruction even after successful antiretroviral therapy (ART). Here, we review some of the potential mechanisms for the loss and dysregulation of Th17 cells during HIV infection. |
| format | Article |
| id | doaj-art-1be8f0aad971482488f60b2493a90f07 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-1be8f0aad971482488f60b2493a90f072025-02-03T05:57:27ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/852418852418Loss and Dysregulation of Th17 Cells during HIV InfectionSandra L. Bixler0Joseph J. Mattapallil1Department of Microbiology & Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USADepartment of Microbiology & Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USABacterial translocation across the damaged mucosal epithelium has emerged as a major paradigm for chronic immune activation observed during HIV infection. T helper 17 (Th17) cells are a unique lineage of T helper cells that are enriched in mucosal tissues and are thought to play a central role in protecting the integrity of the mucosal barrier and maintaining immune homeostasis at mucosal sites. Th17 cells are lost very early during the course of HIV infection, and their loss has been shown to correlate with bacterial translocation. Interestingly, Th17 cells are unable to completely recover from the early destruction even after successful antiretroviral therapy (ART). Here, we review some of the potential mechanisms for the loss and dysregulation of Th17 cells during HIV infection.http://dx.doi.org/10.1155/2013/852418 |
| spellingShingle | Sandra L. Bixler Joseph J. Mattapallil Loss and Dysregulation of Th17 Cells during HIV Infection Clinical and Developmental Immunology |
| title | Loss and Dysregulation of Th17 Cells during HIV Infection |
| title_full | Loss and Dysregulation of Th17 Cells during HIV Infection |
| title_fullStr | Loss and Dysregulation of Th17 Cells during HIV Infection |
| title_full_unstemmed | Loss and Dysregulation of Th17 Cells during HIV Infection |
| title_short | Loss and Dysregulation of Th17 Cells during HIV Infection |
| title_sort | loss and dysregulation of th17 cells during hiv infection |
| url | http://dx.doi.org/10.1155/2013/852418 |
| work_keys_str_mv | AT sandralbixler lossanddysregulationofth17cellsduringhivinfection AT josephjmattapallil lossanddysregulationofth17cellsduringhivinfection |