<i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant
Natural products and botanicals continue to play a very important role in the development of cosmetics worldwide. The chemical constituents of a fine active fraction of the whole plant extract of <i>Cuphea hookeriana</i> Walp., and the tyrosinase and matrix metalloproteinase-1 (MMP-1) in...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/2/311 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587834671759360 |
|---|---|
| author | Xing Wu Meng-Fei Wanyan Bao-Bao Shi Rong Huang Hui-Xiang Yang Xian Wang Ji-Kai Liu |
| author_facet | Xing Wu Meng-Fei Wanyan Bao-Bao Shi Rong Huang Hui-Xiang Yang Xian Wang Ji-Kai Liu |
| author_sort | Xing Wu |
| collection | DOAJ |
| description | Natural products and botanicals continue to play a very important role in the development of cosmetics worldwide. The chemical constituents of a fine active fraction of the whole plant extract of <i>Cuphea hookeriana</i> Walp., and the tyrosinase and matrix metalloproteinase-1 (MMP-1) inhibitory and antioxidant activities of this fraction were investigated. The fine active fraction was mainly composed of seven natural compounds. The fine active fraction demonstrated substantial in vitro antioxidant potential using the ABTS assay (IC<sub>50</sub> 1.66 μg/mL). It inhibited the two target enzymes (tyrosinase and MMP-1) engaged in skin whitening and aging with comparable IC<sub>50</sub> values to the reference drugs. Acute toxicity experiments showed that mice gavage orally with the fine active fraction had no significant animal toxicity at a dose of 2000 mg/kg, and the maximum tolerated dose (MTD) in mice was greater than 2000 mg/kg. In a model where ultraviolet light promotes the increase in melanin secretion in guinea pig skin tissues, both α-arbutin and the fine active fraction can reduce melanogenesis, and the effect of the fine active fraction is better than that of α-arbutin. |
| format | Article |
| id | doaj-art-1be54d5d77fb4311b8d0d571218500fe |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-1be54d5d77fb4311b8d0d571218500fe2025-01-24T13:43:32ZengMDPI AGMolecules1420-30492025-01-0130231110.3390/molecules30020311<i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole PlantXing Wu0Meng-Fei Wanyan1Bao-Bao Shi2Rong Huang3Hui-Xiang Yang4Xian Wang5Ji-Kai Liu6Anhui Province Key Laboratory of Bioactive Natural Products, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaAnhui Province Key Laboratory of Bioactive Natural Products, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaNatural products and botanicals continue to play a very important role in the development of cosmetics worldwide. The chemical constituents of a fine active fraction of the whole plant extract of <i>Cuphea hookeriana</i> Walp., and the tyrosinase and matrix metalloproteinase-1 (MMP-1) inhibitory and antioxidant activities of this fraction were investigated. The fine active fraction was mainly composed of seven natural compounds. The fine active fraction demonstrated substantial in vitro antioxidant potential using the ABTS assay (IC<sub>50</sub> 1.66 μg/mL). It inhibited the two target enzymes (tyrosinase and MMP-1) engaged in skin whitening and aging with comparable IC<sub>50</sub> values to the reference drugs. Acute toxicity experiments showed that mice gavage orally with the fine active fraction had no significant animal toxicity at a dose of 2000 mg/kg, and the maximum tolerated dose (MTD) in mice was greater than 2000 mg/kg. In a model where ultraviolet light promotes the increase in melanin secretion in guinea pig skin tissues, both α-arbutin and the fine active fraction can reduce melanogenesis, and the effect of the fine active fraction is better than that of α-arbutin.https://www.mdpi.com/1420-3049/30/2/311<i>Cuphea hookeriana</i>cosmeceuticaltyrosinasematrix metalloproteinase-1skin whiteningdermatological |
| spellingShingle | Xing Wu Meng-Fei Wanyan Bao-Bao Shi Rong Huang Hui-Xiang Yang Xian Wang Ji-Kai Liu <i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant Molecules <i>Cuphea hookeriana</i> cosmeceutical tyrosinase matrix metalloproteinase-1 skin whitening dermatological |
| title | <i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant |
| title_full | <i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant |
| title_fullStr | <i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant |
| title_full_unstemmed | <i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant |
| title_short | <i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant |
| title_sort | i cuphea hookeriana i phytochemical profile and the cosmeceutical and dermatological properties of its active fraction from the whole plant |
| topic | <i>Cuphea hookeriana</i> cosmeceutical tyrosinase matrix metalloproteinase-1 skin whitening dermatological |
| url | https://www.mdpi.com/1420-3049/30/2/311 |
| work_keys_str_mv | AT xingwu icupheahookerianaiphytochemicalprofileandthecosmeceuticalanddermatologicalpropertiesofitsactivefractionfromthewholeplant AT mengfeiwanyan icupheahookerianaiphytochemicalprofileandthecosmeceuticalanddermatologicalpropertiesofitsactivefractionfromthewholeplant AT baobaoshi icupheahookerianaiphytochemicalprofileandthecosmeceuticalanddermatologicalpropertiesofitsactivefractionfromthewholeplant AT ronghuang icupheahookerianaiphytochemicalprofileandthecosmeceuticalanddermatologicalpropertiesofitsactivefractionfromthewholeplant AT huixiangyang icupheahookerianaiphytochemicalprofileandthecosmeceuticalanddermatologicalpropertiesofitsactivefractionfromthewholeplant AT xianwang icupheahookerianaiphytochemicalprofileandthecosmeceuticalanddermatologicalpropertiesofitsactivefractionfromthewholeplant AT jikailiu icupheahookerianaiphytochemicalprofileandthecosmeceuticalanddermatologicalpropertiesofitsactivefractionfromthewholeplant |