Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal Outcome
Although uncommon during pregnancy, cirrhosis results in multiple medical complications impacting both mother and fetus. Previous reports suggest liver dysfunction in pregnancy causes accumulation of neurotoxins within the maternal compartment that increases neonatal morbidity through placental tran...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2013/507169 |
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| author | Deana J. Hussamy David B. Nelson Stephan A. Shivvers |
| author_facet | Deana J. Hussamy David B. Nelson Stephan A. Shivvers |
| author_sort | Deana J. Hussamy |
| collection | DOAJ |
| description | Although uncommon during pregnancy, cirrhosis results in multiple medical complications impacting both mother and fetus. Previous reports suggest liver dysfunction in pregnancy causes accumulation of neurotoxins within the maternal compartment that increases neonatal morbidity through placental transfer. We present a case of a 36-year-old G2P1 female with history of biliary cirrhosis presenting at 32-weeks' gestation with hepatic congestion progressing to hepatic encephalopathy prompting delivery. Umbilical cord sampling and postnatal infant testing demonstrated elevated ammonia levels which resolved by 12 hours of life without intervention. At discharge, the infant did not demonstrate evidence of neurologic deficit. We conclude that acute maternal hepatic encephalopathy and hyperammonemia due to chronic liver disease do not portend adverse neonatal outcomes, notably encephalopathy. |
| format | Article |
| id | doaj-art-1be54574f8874468ae05c8884d435961 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-1be54574f8874468ae05c8884d4359612025-02-03T06:08:11ZengWileyCase Reports in Critical Care2090-64202090-64392013-01-01201310.1155/2013/507169507169Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal OutcomeDeana J. Hussamy0David B. Nelson1Stephan A. Shivvers2Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, 5323 Harry Hines Boulevard, Dallas, TX 75390-9032, USADepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, 5323 Harry Hines Boulevard, Dallas, TX 75390-9032, USADepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, 5323 Harry Hines Boulevard, Dallas, TX 75390-9032, USAAlthough uncommon during pregnancy, cirrhosis results in multiple medical complications impacting both mother and fetus. Previous reports suggest liver dysfunction in pregnancy causes accumulation of neurotoxins within the maternal compartment that increases neonatal morbidity through placental transfer. We present a case of a 36-year-old G2P1 female with history of biliary cirrhosis presenting at 32-weeks' gestation with hepatic congestion progressing to hepatic encephalopathy prompting delivery. Umbilical cord sampling and postnatal infant testing demonstrated elevated ammonia levels which resolved by 12 hours of life without intervention. At discharge, the infant did not demonstrate evidence of neurologic deficit. We conclude that acute maternal hepatic encephalopathy and hyperammonemia due to chronic liver disease do not portend adverse neonatal outcomes, notably encephalopathy.http://dx.doi.org/10.1155/2013/507169 |
| spellingShingle | Deana J. Hussamy David B. Nelson Stephan A. Shivvers Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal Outcome Case Reports in Critical Care |
| title | Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal Outcome |
| title_full | Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal Outcome |
| title_fullStr | Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal Outcome |
| title_full_unstemmed | Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal Outcome |
| title_short | Hyperammonemia: A Report of Maternal Biliary Cirrhosis and Neonatal Outcome |
| title_sort | hyperammonemia a report of maternal biliary cirrhosis and neonatal outcome |
| url | http://dx.doi.org/10.1155/2013/507169 |
| work_keys_str_mv | AT deanajhussamy hyperammonemiaareportofmaternalbiliarycirrhosisandneonataloutcome AT davidbnelson hyperammonemiaareportofmaternalbiliarycirrhosisandneonataloutcome AT stephanashivvers hyperammonemiaareportofmaternalbiliarycirrhosisandneonataloutcome |