Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF) signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can int...

Full description

Saved in:
Bibliographic Details
Main Authors: Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070536&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items