Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes

Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes

In the past two decades, several tissues have been generated from the differentiation of human pluripotent stem cells (hPSCs) to model development or disease, and for use in drug testing and cell replacement therapies. A frontliner of hPSC-derived tissues used in cell replacement therapies are the p...

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Bibliographic Details
Main Authors: Mohammed Usama, Ying Deng, Yiran Chen, Théa Milland, Mohan Malleshaiah, Yasaman Aghazadeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
beta cells
islets
transplantation
human pluripotent stem cells
vascularization
immune cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1625439/full
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