Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricula...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2017/6570465 |
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| _version_ | 1832545833701081088 |
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| author | Lisheng Lin Miho Takahashi-Igari Yoshiaki Kato Yoshihiro Nozaki Mana Obata Hiromi Hamada Hitoshi Horigome |
| author_facet | Lisheng Lin Miho Takahashi-Igari Yoshiaki Kato Yoshihiro Nozaki Mana Obata Hiromi Hamada Hitoshi Horigome |
| author_sort | Lisheng Lin |
| collection | DOAJ |
| description | We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case. |
| format | Article |
| id | doaj-art-1bce3903329141ae926551d54af45723 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-1bce3903329141ae926551d54af457232025-02-03T07:24:32ZengWileyCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/65704656570465Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q VariantLisheng Lin0Miho Takahashi-Igari1Yoshiaki Kato2Yoshihiro Nozaki3Mana Obata4Hiromi Hamada5Hitoshi Horigome6Department of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, JapanDepartment of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanWe report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.http://dx.doi.org/10.1155/2017/6570465 |
| spellingShingle | Lisheng Lin Miho Takahashi-Igari Yoshiaki Kato Yoshihiro Nozaki Mana Obata Hiromi Hamada Hitoshi Horigome Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant Case Reports in Pediatrics |
| title | Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant |
| title_full | Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant |
| title_fullStr | Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant |
| title_full_unstemmed | Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant |
| title_short | Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant |
| title_sort | prenatal diagnosis of atrioventricular block and qt interval prolongation by fetal magnetocardiography in a fetus with trisomy 18 and scn5a r1193q variant |
| url | http://dx.doi.org/10.1155/2017/6570465 |
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