Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery
Humic acid (HA), a complex organic substance naturally present in soil, peat, and coal, is traditionally referred to as the extract of ''Wujinshi'' (乌金石) in Chinese medicine. It is renowned for its potent anti-inflammatory, analgesic, and blood circulation-promoting properties. H...
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Elsevier
2025-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425005186 |
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| author | Ganglin Wang Ziwei Wang Lin Liu Yejing Zhu Jiali Zhong Jiayi Zhang Lingling Wang Chenguo Zheng Wei Li |
| author_facet | Ganglin Wang Ziwei Wang Lin Liu Yejing Zhu Jiali Zhong Jiayi Zhang Lingling Wang Chenguo Zheng Wei Li |
| author_sort | Ganglin Wang |
| collection | DOAJ |
| description | Humic acid (HA), a complex organic substance naturally present in soil, peat, and coal, is traditionally referred to as the extract of ''Wujinshi'' (乌金石) in Chinese medicine. It is renowned for its potent anti-inflammatory, analgesic, and blood circulation-promoting properties. However, its mechanisms and delivery methods require further exploration. We developed BiHANs, a novel nanoparticle combining bismuth and HA, which exhibits excellent biocompatibility and anti-inflammatory effects in vitro. Orally administered BiHANs accumulate at inflammatory sites in the colon of DSS-induced IBD mice, as confirmed by CT imaging, and prolong intestinal retention. They significantly alleviate acute and chronic intestinal damage by suppressing inflammatory responses, modulating gut microbiota, and targeting macrophage mitochondria to inhibit NF-κB-driven cytokine production. BiHANs also maintain mitochondrial homeostasis and exert antioxidative effects. Furthermore, their performance in CT imaging highlights potential as a theranostic agent. This study demonstrates BiHANs as a promising platform for targeted IBD therapy and diagnosis, combining anti-inflammatory efficacy with imaging capabilities. |
| format | Article |
| id | doaj-art-1bcc1324470145b7abff6ac1b37a1a58 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-1bcc1324470145b7abff6ac1b37a1a582025-08-20T02:23:11ZengElsevierMaterials Today Bio2590-00642025-08-013310194810.1016/j.mtbio.2025.101948Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal deliveryGanglin Wang0Ziwei Wang1Lin Liu2Yejing Zhu3Jiali Zhong4Jiayi Zhang5Lingling Wang6Chenguo Zheng7Wei Li8Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, ChinaKey Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, ChinaKey Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, ChinaKey Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, ChinaKey Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, ChinaKey Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, ChinaKey Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, ChinaDepartment of Coloproctology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Corresponding author.Key Laboratory of Laboratory Medicine, Ministry of Education of China, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China; Corresponding author.Humic acid (HA), a complex organic substance naturally present in soil, peat, and coal, is traditionally referred to as the extract of ''Wujinshi'' (乌金石) in Chinese medicine. It is renowned for its potent anti-inflammatory, analgesic, and blood circulation-promoting properties. However, its mechanisms and delivery methods require further exploration. We developed BiHANs, a novel nanoparticle combining bismuth and HA, which exhibits excellent biocompatibility and anti-inflammatory effects in vitro. Orally administered BiHANs accumulate at inflammatory sites in the colon of DSS-induced IBD mice, as confirmed by CT imaging, and prolong intestinal retention. They significantly alleviate acute and chronic intestinal damage by suppressing inflammatory responses, modulating gut microbiota, and targeting macrophage mitochondria to inhibit NF-κB-driven cytokine production. BiHANs also maintain mitochondrial homeostasis and exert antioxidative effects. Furthermore, their performance in CT imaging highlights potential as a theranostic agent. This study demonstrates BiHANs as a promising platform for targeted IBD therapy and diagnosis, combining anti-inflammatory efficacy with imaging capabilities.http://www.sciencedirect.com/science/article/pii/S2590006425005186Inflammatory bowel diseasesBiHANsROS scavengingGut microbiota modulationCT imaging |
| spellingShingle | Ganglin Wang Ziwei Wang Lin Liu Yejing Zhu Jiali Zhong Jiayi Zhang Lingling Wang Chenguo Zheng Wei Li Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery Materials Today Bio Inflammatory bowel diseases BiHANs ROS scavenging Gut microbiota modulation CT imaging |
| title | Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery |
| title_full | Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery |
| title_fullStr | Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery |
| title_full_unstemmed | Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery |
| title_short | Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery |
| title_sort | alchemizing earth s legacy bismuth engineered humic nanoparticles for ibd theranostics through mitochondrial anti inflammation and sustained intestinal delivery |
| topic | Inflammatory bowel diseases BiHANs ROS scavenging Gut microbiota modulation CT imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425005186 |
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