Juvenile Localized Scleroderma. Questions of Treatment
Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS. The JLS treatment during active phase (when skin lesions are...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2020-08-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/2397 |
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| author | Rinat K. Raupov Mikhail M. Kostik |
| author_facet | Rinat K. Raupov Mikhail M. Kostik |
| author_sort | Rinat K. Raupov |
| collection | DOAJ |
| description | Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS. The JLS treatment during active phase (when skin lesions are reversible) is the most effective. The management is determined by the area and depth of skin lesions, appearance and spread of new lesions, presence of extracutaneous signs of the disease. Topical and systemic immunosuppressants are the basic therapy for JLS. The use of antibiotics is not suggested. Clinical scores (LoSCAT), ultrasound, thermography and magnetic resonance imaging are recommended to estimate the treatment efficacy. |
| format | Article |
| id | doaj-art-1bc923dffbd04b648aa9d7ad46800a0d |
| institution | DOAJ |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-1bc923dffbd04b648aa9d7ad46800a0d2025-08-20T03:01:18Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352020-08-0119322823410.15690/vsp.v19i3.21191879Juvenile Localized Scleroderma. Questions of TreatmentRinat K. Raupov0Mikhail M. Kostik1St. Petersburg State Pediatric Medical UniversitySt. Petersburg State Pediatric Medical UniversityJuvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS. The JLS treatment during active phase (when skin lesions are reversible) is the most effective. The management is determined by the area and depth of skin lesions, appearance and spread of new lesions, presence of extracutaneous signs of the disease. Topical and systemic immunosuppressants are the basic therapy for JLS. The use of antibiotics is not suggested. Clinical scores (LoSCAT), ultrasound, thermography and magnetic resonance imaging are recommended to estimate the treatment efficacy.https://vsp.spr-journal.ru/jour/article/view/2397juvenile localized sclerodermamorphealinear morpheatopical glucocorticosteroidstacrolimusmethotrexatmycophenolate mofetilgenetically engineered biologic drugs |
| spellingShingle | Rinat K. Raupov Mikhail M. Kostik Juvenile Localized Scleroderma. Questions of Treatment Вопросы современной педиатрии juvenile localized scleroderma morphea linear morphea topical glucocorticosteroids tacrolimus methotrexat mycophenolate mofetil genetically engineered biologic drugs |
| title | Juvenile Localized Scleroderma. Questions of Treatment |
| title_full | Juvenile Localized Scleroderma. Questions of Treatment |
| title_fullStr | Juvenile Localized Scleroderma. Questions of Treatment |
| title_full_unstemmed | Juvenile Localized Scleroderma. Questions of Treatment |
| title_short | Juvenile Localized Scleroderma. Questions of Treatment |
| title_sort | juvenile localized scleroderma questions of treatment |
| topic | juvenile localized scleroderma morphea linear morphea topical glucocorticosteroids tacrolimus methotrexat mycophenolate mofetil genetically engineered biologic drugs |
| url | https://vsp.spr-journal.ru/jour/article/view/2397 |
| work_keys_str_mv | AT rinatkraupov juvenilelocalizedsclerodermaquestionsoftreatment AT mikhailmkostik juvenilelocalizedsclerodermaquestionsoftreatment |