Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes
Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance. However, earlier studies using animal...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000987 |
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| author | Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun |
| author_facet | Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun |
| author_sort | Daoming Li |
| collection | DOAJ |
| description | Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance. However, earlier studies using animal models or humans reported that dietary DAGs with a 1,2-DAGs to 1,3-DAGs ratio of approximately 3:7 could improve insulin sensitivity in type 2 diabetic patients. This conflict raises the question of whether there is a link between the ingested DAGs and endogenous DAGs during their metabolism. To make a contribution to this field, this review provides an overview of the metabolic pathways of ingested DAGs and biological roles of DAGs (ingested and endogenous) in the change of insulin sensitivity. Accordingly, strategies for further investigations on the metabolism of DAGs are proposed. |
| format | Article |
| id | doaj-art-1bc409a11f3043f581ae9659be7c581e |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-1bc409a11f3043f581ae9659be7c581e2025-02-03T11:07:46ZengTsinghua University PressFood Science and Human Wellness2213-45302022-03-01112230237Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetesDaoming Li0Yang Zhu1Yonghua Wang2Qiong Zou3Jinzhu Duan4Dongxiao Sun-Waterhouse5Baoguo Sun6Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China; School of Food Science and Engineering, Guangdong Research Center of Lipid Science and Applied Engineering Technology, South China University of Technology, Guangzhou 510640, ChinaBioprocess Engineering, Wageningen University and Research, 6700 AA Wageningen, NetherlandsBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food Science and Engineering, Guangdong Research Center of Lipid Science and Applied Engineering Technology, South China University of Technology, Guangzhou 510640, China; Corresponding author.Guangzhou Yong-h Special Nutrition Technology Co. Ltd, Guangzhou 510000, ChinaGuangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou 510623, ChinaSchool of Food Science and Engineering, Guangdong Research Center of Lipid Science and Applied Engineering Technology, South China University of Technology, Guangzhou 510640, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Corresponding author.Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance. However, earlier studies using animal models or humans reported that dietary DAGs with a 1,2-DAGs to 1,3-DAGs ratio of approximately 3:7 could improve insulin sensitivity in type 2 diabetic patients. This conflict raises the question of whether there is a link between the ingested DAGs and endogenous DAGs during their metabolism. To make a contribution to this field, this review provides an overview of the metabolic pathways of ingested DAGs and biological roles of DAGs (ingested and endogenous) in the change of insulin sensitivity. Accordingly, strategies for further investigations on the metabolism of DAGs are proposed.http://www.sciencedirect.com/science/article/pii/S2213453021000987DiacylglycerolsFunctional oilInsulin sensitivityLipidomics |
| spellingShingle | Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes Food Science and Human Wellness Diacylglycerols Functional oil Insulin sensitivity Lipidomics |
| title | Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes |
| title_full | Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes |
| title_fullStr | Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes |
| title_full_unstemmed | Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes |
| title_short | Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes |
| title_sort | perspectives on diacylglycerol induced improvement of insulin sensitivity in type 2 diabetes |
| topic | Diacylglycerols Functional oil Insulin sensitivity Lipidomics |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000987 |
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