Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites
Bronchial asthma is a chronic inflammatory disease which has become prevalent worldwide. There are millions of new patients and thousands of people die from asthma. Asthma is characterized with infiltration by eosinophils in pulmonary parenchyma, high serum IgE, and cytokines like IL-4, IL-5, and IL...
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Wiley
2018-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2018/3286491 |
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| author | Jian Sun Shiwei Sheng Gang Zhao |
| author_facet | Jian Sun Shiwei Sheng Gang Zhao |
| author_sort | Jian Sun |
| collection | DOAJ |
| description | Bronchial asthma is a chronic inflammatory disease which has become prevalent worldwide. There are millions of new patients and thousands of people die from asthma. Asthma is characterized with infiltration by eosinophils in pulmonary parenchyma, high serum IgE, and cytokines like IL-4, IL-5, and IL-13 secreted by allergen-specific T helper cell-2 (Th2) cells. Products of eosinophils are considered as negative regulators that work on remodeling lung tissue, including airway thickening, fibrosis, and angiogenesis. Achyranthes bidentata polysaccharide (ABPS) is a kind of polysaccharide extracted from the dry root of Achyranthes plant Achyranthes bidentata. ABPS is reported to have multiple biological functions and acts on the human immune system. ABPS can induce production of TNF-α in macrophage, enhance the killing ability of NK cells, and promote the proliferation of B cells. Besides this, ABPS is reported that can induce apoptosis of eosinophils by upregulating the expression of proteins involved in apoptosis. In this study, we constructed chronic allergic asthma mice model induced by house dust mites (HDM) with airway hyperresponsiveness (AHR) and found that anti-IL-5 mAb and ABPS treatment can both decrease inflammatory cells infiltration especially eosinophils and decrease the level of serum IgE and HDM-specific IgG1. The level of IFN-γ is increased and AHR is improved, and a more significant phenomenon was observed in anti-IL-5 mAb and ABPS combined treatment. |
| format | Article |
| id | doaj-art-1bc2271e3c2845f2b12d33734dac5710 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-1bc2271e3c2845f2b12d33734dac57102025-02-03T05:48:11ZengWileyInternational Journal of Polymer Science1687-94221687-94302018-01-01201810.1155/2018/32864913286491Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust MitesJian Sun0Shiwei Sheng1Gang Zhao2Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, ChinaDepartment of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, ChinaDepartment of Emergency, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, ChinaBronchial asthma is a chronic inflammatory disease which has become prevalent worldwide. There are millions of new patients and thousands of people die from asthma. Asthma is characterized with infiltration by eosinophils in pulmonary parenchyma, high serum IgE, and cytokines like IL-4, IL-5, and IL-13 secreted by allergen-specific T helper cell-2 (Th2) cells. Products of eosinophils are considered as negative regulators that work on remodeling lung tissue, including airway thickening, fibrosis, and angiogenesis. Achyranthes bidentata polysaccharide (ABPS) is a kind of polysaccharide extracted from the dry root of Achyranthes plant Achyranthes bidentata. ABPS is reported to have multiple biological functions and acts on the human immune system. ABPS can induce production of TNF-α in macrophage, enhance the killing ability of NK cells, and promote the proliferation of B cells. Besides this, ABPS is reported that can induce apoptosis of eosinophils by upregulating the expression of proteins involved in apoptosis. In this study, we constructed chronic allergic asthma mice model induced by house dust mites (HDM) with airway hyperresponsiveness (AHR) and found that anti-IL-5 mAb and ABPS treatment can both decrease inflammatory cells infiltration especially eosinophils and decrease the level of serum IgE and HDM-specific IgG1. The level of IFN-γ is increased and AHR is improved, and a more significant phenomenon was observed in anti-IL-5 mAb and ABPS combined treatment.http://dx.doi.org/10.1155/2018/3286491 |
| spellingShingle | Jian Sun Shiwei Sheng Gang Zhao Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites International Journal of Polymer Science |
| title | Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites |
| title_full | Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites |
| title_fullStr | Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites |
| title_full_unstemmed | Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites |
| title_short | Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites |
| title_sort | achyranthes bidentata polysaccharide along with anti il 5 antibody inhibits allergic lung inflammation and airway hyperresponsiveness mice induced by house dust mites |
| url | http://dx.doi.org/10.1155/2018/3286491 |
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