PATHOPHYSIOLOGICAL EVALUATION OF THE PROTECTIVE ROLE OF ALPHA LIPOIC ACID ON DIABETES MELLITUS NEPHROPATHY IN MALE RABBITS
In order to estimate the ameliorating effects of alpha lipoic acid (ALA) on the nephropathy of diabetes mellitus (DM) associated with oxidative stress, this study performed in 18 adults male rabbits were divided into 3 equal groups, the group-I was regard as control while group-II Induced DM only by...
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| Format: | Article |
| Language: | English |
| Published: |
College of Veterinary Medicine, University of Basrah, Iraq
2017-06-01
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| Series: | Basrah Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://bjvr.uobasrah.edu.iq/article_127440_ab10669dabd8a8d2dd3855cee8f3dda2.pdf |
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| Summary: | In order to estimate the ameliorating effects of alpha lipoic acid (ALA) on the
nephropathy of diabetes mellitus (DM) associated with oxidative stress, this study
performed in 18 adults male rabbits were divided into 3 equal groups, the group-I was
regard as control while group-II Induced DM only by intravenously single dose (150
mg/kg b.w.) of alloxan-monohydrate; group-III was induced DM by intravenously
single dose of (150mg/kg b.w.) of alloxan-monohydrate and then treated by (10mg/kg
b.w.) daily of ALA intraperitoneally for 4 weeks. The biochemical results showed
significant (P≤0.05) decreased of the serum values of GSH, CAT and SOD as well,
significantly (P≤0.05) increased of MDA, peroxynitrate, creatinine and BUN of
group-II when compared to control; also the result of group-III showed nonsignificant
(P˃0.05) differences of GSH, SOD, MDA, creatinine, BUN and
peroxynitrate when compared to control. The histopathological and histochemical
results of kidney of group-II showed moderate thickness of basement membrane of
glomeruli with compressed capillaries as well infiltration of glyco-proteinaceous
materials in glomeruli and around renal tubules with some vacuolation of these
tubules and mesangial cells; while the results of group-III showed normal
architectures with very mild degree of vacuolation of few renal tubules in addition to
disappearance of glyco- proteinaceous materials in this group; in conclusion, ALA
had a dual protective effects on nephropathy by scavenging the oxidative stress free
radicals and enhanced insulin metabolism. |
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| ISSN: | 1813-8497 2410-8456 |