On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis

On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis

Abstract The lack of clinically predictive potency assays for cell products significantly impedes translation of these therapies. Here, we describe a microfluidic on-chip 3D system for rapid evaluation of a subset of patient-derived bone marrow aspirate concentrate (BMAC) samples used in a phase 3 m...

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Main Authors: Rebecca S. Schneider, Elisa B. Nieves, Bhavay Aggarwal, Annie C. Bowles-Welch, Hazel Y. Stevens, Linda E. Kippner, Scott D. Boden, Kenneth Mautner, Hicham Drissi, Krishnendu Roy, Wilbur A. Lam, Saurabh Sinha, Andrés J. García
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60158-w
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https://doi.org/10.1038/s41467-025-60158-w

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