Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine

Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine

Abstract Borrelia burgdorferi (Bb) causes Lyme disease (LD), one of the most common vector-borne diseases in the Northern Hemisphere. Here, we solve the crystal structure of a mutated Bb vaccine antigen, CspZ-YA that lacks the ability to bind to host complement factor H (FH). We generate point mutan...

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Main Authors: Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen, Yi-Pin Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58182-x
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https://doi.org/10.1038/s41467-025-58182-x

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