Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications
The purpose of this study was to fabricate chitosan/poly(vinyl alcohol)/Ag nanoparticles (CPA) gels with microwave-assistance for skin applications. Microwave irradiation was employed to reduce silver ions to silver nanoparticles and to crosslink chitosan (CS) with polyvinyl alcohol (PVA). The prese...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2016/1584046 |
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| author | Nguyen Thi Hiep Huynh Chan Khon Vo Van Thanh Niem Vo Van Toi Tran Ngoc Quyen Nguyen Dai Hai Mai Ngoc Tuan Anh |
| author_facet | Nguyen Thi Hiep Huynh Chan Khon Vo Van Thanh Niem Vo Van Toi Tran Ngoc Quyen Nguyen Dai Hai Mai Ngoc Tuan Anh |
| author_sort | Nguyen Thi Hiep |
| collection | DOAJ |
| description | The purpose of this study was to fabricate chitosan/poly(vinyl alcohol)/Ag nanoparticles (CPA) gels with microwave-assistance for skin applications. Microwave irradiation was employed to reduce silver ions to silver nanoparticles and to crosslink chitosan (CS) with polyvinyl alcohol (PVA). The presence of silver nanoparticles in CPA gels matrix was examined using UV-Vis spectroscopy, transmission electron microscopy, and X-ray diffraction. The interaction of CS and PVA was analysed by Fourier transform infrared spectroscopy. The release of silver ions was determined by atomic absorption spectrometry. The antimicrobial properties of CPA gels against P. aeruginosa and S. aureus were investigated using agar diffusion method. Finally, the biocompatibility and wound-healing ability of the gels were studied using fibroblast cells (in vitro) and mice models (in vivo). In conclusion, the results showed that CPA gels were successfully fabricated using microwave irradiation method. These gels can be applied to heal an open wound thanks to their antibacterial activity and biocompatibility. |
| format | Article |
| id | doaj-art-1b9c72bde92a4a52a5e1b88286fb4e80 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-1b9c72bde92a4a52a5e1b88286fb4e802025-02-03T01:03:45ZengWileyInternational Journal of Polymer Science1687-94221687-94302016-01-01201610.1155/2016/15840461584046Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing ApplicationsNguyen Thi Hiep0Huynh Chan Khon1Vo Van Thanh Niem2Vo Van Toi3Tran Ngoc Quyen4Nguyen Dai Hai5Mai Ngoc Tuan Anh6Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City (VNU-HCMC), HCMC 700000, VietnamThe Center for Molecular Biomedicine, University of Medicine and Pharmacy, HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City (VNU-HCMC), HCMC 700000, VietnamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, HCMC 700000, VietnamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, HCMC 700000, VietnamResearch Laboratories of Saigon Hi-Tech Park, HCMC 700000, VietnamThe purpose of this study was to fabricate chitosan/poly(vinyl alcohol)/Ag nanoparticles (CPA) gels with microwave-assistance for skin applications. Microwave irradiation was employed to reduce silver ions to silver nanoparticles and to crosslink chitosan (CS) with polyvinyl alcohol (PVA). The presence of silver nanoparticles in CPA gels matrix was examined using UV-Vis spectroscopy, transmission electron microscopy, and X-ray diffraction. The interaction of CS and PVA was analysed by Fourier transform infrared spectroscopy. The release of silver ions was determined by atomic absorption spectrometry. The antimicrobial properties of CPA gels against P. aeruginosa and S. aureus were investigated using agar diffusion method. Finally, the biocompatibility and wound-healing ability of the gels were studied using fibroblast cells (in vitro) and mice models (in vivo). In conclusion, the results showed that CPA gels were successfully fabricated using microwave irradiation method. These gels can be applied to heal an open wound thanks to their antibacterial activity and biocompatibility.http://dx.doi.org/10.1155/2016/1584046 |
| spellingShingle | Nguyen Thi Hiep Huynh Chan Khon Vo Van Thanh Niem Vo Van Toi Tran Ngoc Quyen Nguyen Dai Hai Mai Ngoc Tuan Anh Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications International Journal of Polymer Science |
| title | Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications |
| title_full | Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications |
| title_fullStr | Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications |
| title_full_unstemmed | Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications |
| title_short | Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications |
| title_sort | microwave assisted synthesis of chitosan polyvinyl alcohol silver nanoparticles gel for wound dressing applications |
| url | http://dx.doi.org/10.1155/2016/1584046 |
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