Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease that targets myelinated axons in the central nervous system (CNS). Cancer of unknown primary site (CUP) is a well-recognised clinical disorder, accounting for 3–5% of all malignant epithelial tumors. CUP is clinically characterised as an aggres...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/135976 |
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| author | Stergios Boussios Vasiliki Kostadima Anna Batistatou Ioannis Tourkantonis George Fotopoulos Maria I. Argyropoulou Nicholas Pavlidis |
| author_facet | Stergios Boussios Vasiliki Kostadima Anna Batistatou Ioannis Tourkantonis George Fotopoulos Maria I. Argyropoulou Nicholas Pavlidis |
| author_sort | Stergios Boussios |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic autoimmune disease that targets myelinated axons in the central nervous system (CNS). Cancer of unknown primary site (CUP) is a well-recognised clinical disorder, accounting for 3–5% of all malignant epithelial tumors. CUP is clinically characterised as an aggressive disease with early dissemination. Studies of cancer risk in MS patients have shown inconsistent findings. An increased risk of malignancy in patients with MS has been suggested, but recently serious questions have been raised regarding this association. Use of disease-modifying therapies might contribute to an increased cancer risk in selected MS patients. The concurrence of MS and CUP is exceptionally rare. Here we describe the case of a neuroendocrine carcinoma of unknown primary diagnosed in a male patient with a nine-year history of MS. The discussion includes data from all available population-based register studies with estimates of certain malignancies in patients with MS. |
| format | Article |
| id | doaj-art-1b9323e87b1640fabab502ef9d9efd38 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-1b9323e87b1640fabab502ef9d9efd382025-02-03T01:11:22ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/135976135976Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple SclerosisStergios Boussios0Vasiliki Kostadima1Anna Batistatou2Ioannis Tourkantonis3George Fotopoulos4Maria I. Argyropoulou5Nicholas Pavlidis6Department of Medical Oncology, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Neurology, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Pathology, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Medical Oncology, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Medical Oncology, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Radiology, Medical School, University of Ioannina, 45110 Ioannina, GreeceDepartment of Medical Oncology, Medical School, University of Ioannina, 45110 Ioannina, GreeceMultiple sclerosis (MS) is a chronic autoimmune disease that targets myelinated axons in the central nervous system (CNS). Cancer of unknown primary site (CUP) is a well-recognised clinical disorder, accounting for 3–5% of all malignant epithelial tumors. CUP is clinically characterised as an aggressive disease with early dissemination. Studies of cancer risk in MS patients have shown inconsistent findings. An increased risk of malignancy in patients with MS has been suggested, but recently serious questions have been raised regarding this association. Use of disease-modifying therapies might contribute to an increased cancer risk in selected MS patients. The concurrence of MS and CUP is exceptionally rare. Here we describe the case of a neuroendocrine carcinoma of unknown primary diagnosed in a male patient with a nine-year history of MS. The discussion includes data from all available population-based register studies with estimates of certain malignancies in patients with MS.http://dx.doi.org/10.1155/2015/135976 |
| spellingShingle | Stergios Boussios Vasiliki Kostadima Anna Batistatou Ioannis Tourkantonis George Fotopoulos Maria I. Argyropoulou Nicholas Pavlidis Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis Case Reports in Oncological Medicine |
| title | Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis |
| title_full | Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis |
| title_fullStr | Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis |
| title_full_unstemmed | Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis |
| title_short | Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis |
| title_sort | neuroendocrine cell carcinoma of unknown primary arising in long standing history of multiple sclerosis |
| url | http://dx.doi.org/10.1155/2015/135976 |
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