Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology

Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology

ABSTRACT Background This study investigates the native presence and potential anabolic effects of interleukin (IL)‐4 and IL‐10 in the human intervertebral disc (IVD). Methods Human nucleus pulposus (NP) cells cultured in 3D from trauma and degenerate IVDs and NP explants were stimulated with 10 ng/m...

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Main Authors: Paola Bermudez‐Lekerika, Sofia Tseranidou, Exarchos Kanelis, Andrea Nüesch, Katherine B. Crump, Leonidas G. Alexopoulos, Karin Wuertz‐Kozak, Jérôme Noailly, Christine L. Le Maitre, Benjamin Gantenbein
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:JOR Spine
Subjects:
immunohistochemistry
interleukin‐10
interleukin‐4
intervertebral disc
low back pain
secretome proteomics
Online Access:https://doi.org/10.1002/jsp2.70048
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