Immunotherapy of osteosarcoma based on immune microenvironment modulation
Osteosarcoma is a highly malignant tumor with unsatisfactory therapeutic outcomes achieved by chemotherapy, radiotherapy, and surgery. As an emerging oncological treatment, immunotherapy has shown potential in the clinical management of many tumors but has a poor response rate in osteosarcoma. The i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1498060/full |
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| author | Heping Lian Heping Lian Jiakui Zhang Shuna Hou Shuang Ma Jiachen Yu Wei Zhao Duoyi Zhao Zhiyu Zhang |
| author_facet | Heping Lian Heping Lian Jiakui Zhang Shuna Hou Shuang Ma Jiachen Yu Wei Zhao Duoyi Zhao Zhiyu Zhang |
| author_sort | Heping Lian |
| collection | DOAJ |
| description | Osteosarcoma is a highly malignant tumor with unsatisfactory therapeutic outcomes achieved by chemotherapy, radiotherapy, and surgery. As an emerging oncological treatment, immunotherapy has shown potential in the clinical management of many tumors but has a poor response rate in osteosarcoma. The immunosuppressive microenvironment in osteosarcoma is the main reason for the ineffectiveness of immunotherapy, in which the low immune response rate of immune effector cells and the high activation of immunosuppressive cells contribute to this outcome. Therefore, modulating the function of the immune microenvironment in osteosarcoma is expected to remodel the immunosuppressive microenvironment of osteosarcoma and enhance the efficacy of immunotherapy. This article reviews the role of immune cells in the progression of osteosarcoma, describes the corresponding regulatory tools for the characteristics of different cells to enhance the efficacy of osteosarcoma immunotherapy, and concludes the prospects and future challenges of osteosarcoma immunotherapy. |
| format | Article |
| id | doaj-art-1b71e7842af7408c86d2d6adad6bb0e7 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1b71e7842af7408c86d2d6adad6bb0e72025-01-23T06:56:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14980601498060Immunotherapy of osteosarcoma based on immune microenvironment modulationHeping Lian0Heping Lian1Jiakui Zhang2Shuna Hou3Shuang Ma4Jiachen Yu5Wei Zhao6Duoyi Zhao7Zhiyu Zhang8Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaBone and Soft Tissue Tumours Research Centre of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), Kunming, ChinaDepartment of Surgical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaNursing Department, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaOsteosarcoma is a highly malignant tumor with unsatisfactory therapeutic outcomes achieved by chemotherapy, radiotherapy, and surgery. As an emerging oncological treatment, immunotherapy has shown potential in the clinical management of many tumors but has a poor response rate in osteosarcoma. The immunosuppressive microenvironment in osteosarcoma is the main reason for the ineffectiveness of immunotherapy, in which the low immune response rate of immune effector cells and the high activation of immunosuppressive cells contribute to this outcome. Therefore, modulating the function of the immune microenvironment in osteosarcoma is expected to remodel the immunosuppressive microenvironment of osteosarcoma and enhance the efficacy of immunotherapy. This article reviews the role of immune cells in the progression of osteosarcoma, describes the corresponding regulatory tools for the characteristics of different cells to enhance the efficacy of osteosarcoma immunotherapy, and concludes the prospects and future challenges of osteosarcoma immunotherapy.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1498060/fullimmunotherapyimmune microenvironmentbiomaterialstargeted therapyosteosarcoma |
| spellingShingle | Heping Lian Heping Lian Jiakui Zhang Shuna Hou Shuang Ma Jiachen Yu Wei Zhao Duoyi Zhao Zhiyu Zhang Immunotherapy of osteosarcoma based on immune microenvironment modulation Frontiers in Immunology immunotherapy immune microenvironment biomaterials targeted therapy osteosarcoma |
| title | Immunotherapy of osteosarcoma based on immune microenvironment modulation |
| title_full | Immunotherapy of osteosarcoma based on immune microenvironment modulation |
| title_fullStr | Immunotherapy of osteosarcoma based on immune microenvironment modulation |
| title_full_unstemmed | Immunotherapy of osteosarcoma based on immune microenvironment modulation |
| title_short | Immunotherapy of osteosarcoma based on immune microenvironment modulation |
| title_sort | immunotherapy of osteosarcoma based on immune microenvironment modulation |
| topic | immunotherapy immune microenvironment biomaterials targeted therapy osteosarcoma |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1498060/full |
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