Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy
Retinopathy is a debilitating vascular complication of diabetes. As with other diabetic complications, diabetic retinopathy (DR) is characterized by the metabolic memory, which has been observed both in DR patients and in DR animal models. Evidences have provided that after a period of poor glucose...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/789120 |
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| author | Lorena Perrone Carmela Matrone Lalit P. Singh |
| author_facet | Lorena Perrone Carmela Matrone Lalit P. Singh |
| author_sort | Lorena Perrone |
| collection | DOAJ |
| description | Retinopathy is a debilitating vascular complication of diabetes. As with other diabetic complications, diabetic retinopathy (DR) is characterized by the metabolic memory, which has been observed both in DR patients and in DR animal models. Evidences have provided that after a period of poor glucose control insulin or diabetes drug treatment fails to prevent the development and progression of DR even when good glycemic control is reinstituted (glucose normalization), suggesting a metabolic memory phenomenon. Recent studies also underline the role of epigenetic chromatin modifications as mediators of the metabolic memory. Indeed, epigenetic changes may lead to stable modification of gene expression, participating in DR pathogenesis. Moreover, increasing evidences suggest that environmental factors such as chronic hyperglycemia are implicated DR progression and may also affect the epigenetic state. Here we review recent findings demonstrating the key role of epigenetics in the progression of DR. Further elucidation of epigenetic mechanisms, acting both at the cis- and trans-chromatin structural elements, will yield new insights into the pathogenesis of DR and will open the way for the discovery of novel therapeutic targets to prevent DR progression. |
| format | Article |
| id | doaj-art-1b547f046ee2426b897812521e19b3a2 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-1b547f046ee2426b897812521e19b3a22025-02-03T06:10:54ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/789120789120Epigenetic Modifications and Potential New Treatment Targets in Diabetic RetinopathyLorena Perrone0Carmela Matrone1Lalit P. Singh2EA 7281 R2D2, Medical School, Auvergne University, 63000 Clermont-Ferrand, FranceDepartment of Biomedicine, University of Aarhus, 8200 Aarhus, DenmarkDepartments of Anatomy/Cell Biology and Ophthalmology, Wayne State University School of Medicine, Detroit, MI 48201, USARetinopathy is a debilitating vascular complication of diabetes. As with other diabetic complications, diabetic retinopathy (DR) is characterized by the metabolic memory, which has been observed both in DR patients and in DR animal models. Evidences have provided that after a period of poor glucose control insulin or diabetes drug treatment fails to prevent the development and progression of DR even when good glycemic control is reinstituted (glucose normalization), suggesting a metabolic memory phenomenon. Recent studies also underline the role of epigenetic chromatin modifications as mediators of the metabolic memory. Indeed, epigenetic changes may lead to stable modification of gene expression, participating in DR pathogenesis. Moreover, increasing evidences suggest that environmental factors such as chronic hyperglycemia are implicated DR progression and may also affect the epigenetic state. Here we review recent findings demonstrating the key role of epigenetics in the progression of DR. Further elucidation of epigenetic mechanisms, acting both at the cis- and trans-chromatin structural elements, will yield new insights into the pathogenesis of DR and will open the way for the discovery of novel therapeutic targets to prevent DR progression.http://dx.doi.org/10.1155/2014/789120 |
| spellingShingle | Lorena Perrone Carmela Matrone Lalit P. Singh Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy Journal of Ophthalmology |
| title | Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy |
| title_full | Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy |
| title_fullStr | Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy |
| title_full_unstemmed | Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy |
| title_short | Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy |
| title_sort | epigenetic modifications and potential new treatment targets in diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2014/789120 |
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