Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particles
Asian sand dust (ASD), a significant desert sand dust, contains sub-2.5 µm fine particles and adversely affects human health, particularly exacerbating respiratory diseases. Despite this, the intricate physiological responses triggered by inhaled ASD particles remain incompletely understood. This st...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024007645 |
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| author | Tomoya Sagawa Takamichi Ichinose Akiko Honda Etsushi Kuroda Raga Ishikawa Natsuko Miyasaka Megumi Nagao Tomoaki Okuda Yutaka Kawahito Hirohisa Takano |
| author_facet | Tomoya Sagawa Takamichi Ichinose Akiko Honda Etsushi Kuroda Raga Ishikawa Natsuko Miyasaka Megumi Nagao Tomoaki Okuda Yutaka Kawahito Hirohisa Takano |
| author_sort | Tomoya Sagawa |
| collection | DOAJ |
| description | Asian sand dust (ASD), a significant desert sand dust, contains sub-2.5 µm fine particles and adversely affects human health, particularly exacerbating respiratory diseases. Despite this, the intricate physiological responses triggered by inhaled ASD particles remain incompletely understood. This study aimed to comprehensively examine the respiratory effects of ASD, focusing on the spatial distribution of inhaled ASD fine particles within the lungs and the immediate physiological responses they incite. Intratracheal administration of ASD fine particles in mice resulted in efficient phagocytosis by alveolar macrophages (AMs), leading to subsequent neutrophilic inflammation. A subset of ASD-phagocytosed AMs underwent necroptosis, releasing interleukin-1α (IL-1α), causing an increase in chemokines and neutrophils. These responses occurred rapidly within hours of exposure, with endotoxin in ASD particles contributing to the process. Despite variations in desert sand dust composition based on collection locale and timing, this study’s findings provide a foundational basis for understanding the biological effects of desert sand dust. Insights gained into the biological responses to desert sand dust hold promise for developing preventive measures such as air purifiers, and therapeutic agents such as IL-1α neutralizing antibodies, antibacterial agents and cell death inhibitors for human diseases associated with such environmental exposures. |
| format | Article |
| id | doaj-art-1b4ad3b033fc4cfab4cffdedb5671663 |
| institution | OA Journals |
| issn | 0160-4120 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-1b4ad3b033fc4cfab4cffdedb56716632025-08-20T02:34:34ZengElsevierEnvironment International0160-41202024-12-0119410917810.1016/j.envint.2024.109178Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particlesTomoya Sagawa0Takamichi Ichinose1Akiko Honda2Etsushi Kuroda3Raga Ishikawa4Natsuko Miyasaka5Megumi Nagao6Tomoaki Okuda7Yutaka Kawahito8Hirohisa Takano9Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; Corresponding author at: Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan.Graduate School of Global Environmental Studies, Kyoto University, Kyoto, JapanDepartment of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, JapanDepartment of Immunology, School of Medicine, Hyogo Medical University, Hyogo, JapanGraduate School of Global Environmental Studies, Kyoto University, Kyoto, JapanGraduate School of Global Environmental Studies, Kyoto University, Kyoto, JapanGraduate School of Global Environmental Studies, Kyoto University, Kyoto, JapanFaculty of Science and Technology, Keio University, Kanagawa, JapanInflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanGraduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan; Institute for International Academic Research, Kyoto University of Advanced Science, Kyoto, JapanAsian sand dust (ASD), a significant desert sand dust, contains sub-2.5 µm fine particles and adversely affects human health, particularly exacerbating respiratory diseases. Despite this, the intricate physiological responses triggered by inhaled ASD particles remain incompletely understood. This study aimed to comprehensively examine the respiratory effects of ASD, focusing on the spatial distribution of inhaled ASD fine particles within the lungs and the immediate physiological responses they incite. Intratracheal administration of ASD fine particles in mice resulted in efficient phagocytosis by alveolar macrophages (AMs), leading to subsequent neutrophilic inflammation. A subset of ASD-phagocytosed AMs underwent necroptosis, releasing interleukin-1α (IL-1α), causing an increase in chemokines and neutrophils. These responses occurred rapidly within hours of exposure, with endotoxin in ASD particles contributing to the process. Despite variations in desert sand dust composition based on collection locale and timing, this study’s findings provide a foundational basis for understanding the biological effects of desert sand dust. Insights gained into the biological responses to desert sand dust hold promise for developing preventive measures such as air purifiers, and therapeutic agents such as IL-1α neutralizing antibodies, antibacterial agents and cell death inhibitors for human diseases associated with such environmental exposures.http://www.sciencedirect.com/science/article/pii/S0160412024007645Desert sand dustAsian sand dustNecroptosisIL-1αAlveolar macrophages |
| spellingShingle | Tomoya Sagawa Takamichi Ichinose Akiko Honda Etsushi Kuroda Raga Ishikawa Natsuko Miyasaka Megumi Nagao Tomoaki Okuda Yutaka Kawahito Hirohisa Takano Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particles Environment International Desert sand dust Asian sand dust Necroptosis IL-1α Alveolar macrophages |
| title | Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particles |
| title_full | Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particles |
| title_fullStr | Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particles |
| title_full_unstemmed | Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particles |
| title_short | Acceleration of acute lung inflammation by IL-1α released through cell death of alveolar macrophages upon phagocytosis of fine Asian sand dust particles |
| title_sort | acceleration of acute lung inflammation by il 1α released through cell death of alveolar macrophages upon phagocytosis of fine asian sand dust particles |
| topic | Desert sand dust Asian sand dust Necroptosis IL-1α Alveolar macrophages |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024007645 |
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