Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
Peripheral nerve injury can lead to sensory, motor, and autonomic nerve dysfunction, significantly impacting patients’ quality of life. Schwann cells (SCs), as key components of the peripheral nervous system, play a crucial role in nerve repair. However, many functionally specialized and flexible SC...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2025-05-01
|
| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2025-1186 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850106292277870592 |
|---|---|
| author | Lan Xianfeng Zheng Yanmei You Yongliang Wu Xuejun Wu Shaojie Chen Nengfu Wang Lihong Yang Wenfu |
| author_facet | Lan Xianfeng Zheng Yanmei You Yongliang Wu Xuejun Wu Shaojie Chen Nengfu Wang Lihong Yang Wenfu |
| author_sort | Lan Xianfeng |
| collection | DOAJ |
| description | Peripheral nerve injury can lead to sensory, motor, and autonomic nerve dysfunction, significantly impacting patients’ quality of life. Schwann cells (SCs), as key components of the peripheral nervous system, play a crucial role in nerve repair. However, many functionally specialized and flexible SC subtypes remain unidentified. Recent advancements in single-cell transcriptomics have enabled a deeper understanding of SC heterogeneity during peripheral nervous system development. |
| format | Article |
| id | doaj-art-1b45a1bd422c4ba7a0da1e858d9f7bbf |
| institution | OA Journals |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-1b45a1bd422c4ba7a0da1e858d9f7bbf2025-08-20T02:38:52ZengDe GruyterOpen Medicine2391-54632025-05-012013910.1515/med-2025-1186Single-cell transcriptomic analysis identifies a stress response Schwann cell subtypeLan Xianfeng0Zheng Yanmei1You Yongliang2Wu Xuejun3Wu Shaojie4Chen Nengfu5Wang Lihong6Yang Wenfu7Department of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaDepartment of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaDepartment of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaDepartment of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaDepartment of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaDepartment of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaDepartment of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaDepartment of Orthopaedics, Fuzhou Second General Hospital, Fuzhou, 350007, ChinaPeripheral nerve injury can lead to sensory, motor, and autonomic nerve dysfunction, significantly impacting patients’ quality of life. Schwann cells (SCs), as key components of the peripheral nervous system, play a crucial role in nerve repair. However, many functionally specialized and flexible SC subtypes remain unidentified. Recent advancements in single-cell transcriptomics have enabled a deeper understanding of SC heterogeneity during peripheral nervous system development.https://doi.org/10.1515/med-2025-1186ingle-cell rna sequencingperipheral nerve injurystress responseschwann celldevelopmental trajectory |
| spellingShingle | Lan Xianfeng Zheng Yanmei You Yongliang Wu Xuejun Wu Shaojie Chen Nengfu Wang Lihong Yang Wenfu Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype Open Medicine ingle-cell rna sequencing peripheral nerve injury stress response schwann cell developmental trajectory |
| title | Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype |
| title_full | Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype |
| title_fullStr | Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype |
| title_full_unstemmed | Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype |
| title_short | Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype |
| title_sort | single cell transcriptomic analysis identifies a stress response schwann cell subtype |
| topic | ingle-cell rna sequencing peripheral nerve injury stress response schwann cell developmental trajectory |
| url | https://doi.org/10.1515/med-2025-1186 |
| work_keys_str_mv | AT lanxianfeng singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype AT zhengyanmei singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype AT youyongliang singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype AT wuxuejun singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype AT wushaojie singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype AT chennengfu singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype AT wanglihong singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype AT yangwenfu singlecelltranscriptomicanalysisidentifiesastressresponseschwanncellsubtype |