Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review
We report an elderly male with mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) and oligometastatic lung involvement, initially diagnosed as benign prostatic hyperplasia and treated with transurethral plasma resection of the prostate (TURP). Postoperative pathology indicated mu...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1494952/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832593397492219904 |
|---|---|
| author | Ao Yu Ao Yu Hongbo Su Peiling Yu Siqi Cai Shuaixian Mu Jinhui Yu Qianting Lu Yuan Miao Ailin Li |
| author_facet | Ao Yu Ao Yu Hongbo Su Peiling Yu Siqi Cai Shuaixian Mu Jinhui Yu Qianting Lu Yuan Miao Ailin Li |
| author_sort | Ao Yu |
| collection | DOAJ |
| description | We report an elderly male with mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) and oligometastatic lung involvement, initially diagnosed as benign prostatic hyperplasia and treated with transurethral plasma resection of the prostate (TURP). Postoperative pathology indicated mucinous adenocarcinoma, with immunohistochemistry positive for CK7, CK20, and CDX-2. Next-generation sequencing (NGS) identified genetic alterations similar to those found in intestinal adenocarcinoma. After ruling out gastrointestinal and bladder tumors, MPUAP was confirmed. Ablation therapy was performed for the lung metastasis, followed by radical prostate chemoradiotherapy. Post chemoradiotherapy, the patient received XELOX + Bevacizumab regmien but switched to capecitabine monotherapy due to adverse effects. At a 12-month follow-up post-radiotherapy, no prostate recurrence was observed, though previous lung nodule ablation suggested recurrence. By reviewing historical cases, we discussed the role and significance of radical resection and TURP in MPUAP. NGS is recommended for patients with MPUAP, and regarding chemotherapy, treatment options for colorectal cancer are worth considering. |
| format | Article |
| id | doaj-art-1b31e3645e574a7f99f9a5c175467311 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-1b31e3645e574a7f99f9a5c1754673112025-01-20T17:08:46ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14949521494952Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature reviewAo Yu0Ao Yu1Hongbo Su2Peiling Yu3Siqi Cai4Shuaixian Mu5Jinhui Yu6Qianting Lu7Yuan Miao8Ailin Li9Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, Liaoning, ChinaSchool of Graduate, China Medical University, Shenyang, ChinaDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, Liaoning, ChinaDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, Liaoning, ChinaDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, ChinaDepartment of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Cancer Hospital of Dalian University of Technology, Shenyang, Liaoning, ChinaWe report an elderly male with mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) and oligometastatic lung involvement, initially diagnosed as benign prostatic hyperplasia and treated with transurethral plasma resection of the prostate (TURP). Postoperative pathology indicated mucinous adenocarcinoma, with immunohistochemistry positive for CK7, CK20, and CDX-2. Next-generation sequencing (NGS) identified genetic alterations similar to those found in intestinal adenocarcinoma. After ruling out gastrointestinal and bladder tumors, MPUAP was confirmed. Ablation therapy was performed for the lung metastasis, followed by radical prostate chemoradiotherapy. Post chemoradiotherapy, the patient received XELOX + Bevacizumab regmien but switched to capecitabine monotherapy due to adverse effects. At a 12-month follow-up post-radiotherapy, no prostate recurrence was observed, though previous lung nodule ablation suggested recurrence. By reviewing historical cases, we discussed the role and significance of radical resection and TURP in MPUAP. NGS is recommended for patients with MPUAP, and regarding chemotherapy, treatment options for colorectal cancer are worth considering.https://www.frontiersin.org/articles/10.3389/fmed.2024.1494952/fullmucin-producing adenocarcinomaurothelial-type adenocarcinomaprostategene sequencingradiotherapy |
| spellingShingle | Ao Yu Ao Yu Hongbo Su Peiling Yu Siqi Cai Shuaixian Mu Jinhui Yu Qianting Lu Yuan Miao Ailin Li Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review Frontiers in Medicine mucin-producing adenocarcinoma urothelial-type adenocarcinoma prostate gene sequencing radiotherapy |
| title | Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review |
| title_full | Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review |
| title_fullStr | Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review |
| title_full_unstemmed | Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review |
| title_short | Mucin-producing urothelial-type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma: case report and literature review |
| title_sort | mucin producing urothelial type adenocarcinoma of the prostate with a gene mutation characteristic of intestinal adenocarcinoma case report and literature review |
| topic | mucin-producing adenocarcinoma urothelial-type adenocarcinoma prostate gene sequencing radiotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1494952/full |
| work_keys_str_mv | AT aoyu mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT aoyu mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT hongbosu mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT peilingyu mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT siqicai mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT shuaixianmu mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT jinhuiyu mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT qiantinglu mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT yuanmiao mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview AT ailinli mucinproducingurothelialtypeadenocarcinomaoftheprostatewithagenemutationcharacteristicofintestinaladenocarcinomacasereportandliteraturereview |