OCT4 translationally promotes AKT signaling as an RNA-binding protein in stressed pluripotent stem cells

OCT4 translationally promotes AKT signaling as an RNA-binding protein in stressed pluripotent stem cells

Abstract Background Despite numerous studies addressing the molecular mechanisms by which pluripotent stem cells (PSCs) maintain self-renewal and pluripotency under normal culture conditions, the fundamental question of how PSCs manage to survive stressful conditions remains largely unresolved. Post...

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Main Authors: Wenjie Chen, Xinyu Chen, Cheng Chen, Shiqi She, Xia Li, Lina Shan, Xiaobing Zhang, Songsong Dan, Yisha Wang, Yan-Wen Zhou, Qingyi Cao, Wenxin Wang, Jianwen Hu, Yaxun Wei, Yaqiang Xue, Yi Zhang, Songying Zhang, Ying-Jie Wang, Bo Kang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
OCT4
AKT
RNA-binding protein (RBP)
Translation initiation
Oxidative stress
Pluripotent stem cells (PSCs)
Online Access:https://doi.org/10.1186/s13287-025-04229-1
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https://doi.org/10.1186/s13287-025-04229-1

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