Antioxidant Functions of the Aryl Hydrocarbon Receptor
The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endog...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7943495 |
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| author | Cornelia Dietrich |
| author_facet | Cornelia Dietrich |
| author_sort | Cornelia Dietrich |
| collection | DOAJ |
| description | The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Binding of the ligand leads to dimerization of the AhR with aryl hydrocarbon receptor nuclear translocator (ARNT) and transcriptional activation of several xenobiotic phase I and phase II metabolizing enzymes. It is generally accepted that the toxic responses of polycyclic aromatic hydrocarbons, dioxins, and structurally related compounds are mediated by activation of the AhR. A multitude of studies indicate that the AhR operates beyond xenobiotic metabolism and exerts pleiotropic functions. Increasing evidence points to a protective role of the AhR against carcinogenesis and oxidative stress. Herein, I will highlight data demonstrating a causal role of the AhR in the antioxidant response and present novel findings on potential AhR-mediated antioxidative mechanisms. |
| format | Article |
| id | doaj-art-1b248db4539e4e758eb9033af82bd924 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1b248db4539e4e758eb9033af82bd9242025-02-03T01:02:11ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/79434957943495Antioxidant Functions of the Aryl Hydrocarbon ReceptorCornelia Dietrich0Institute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacherstr. 67, 55131 Mainz, GermanyThe aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Binding of the ligand leads to dimerization of the AhR with aryl hydrocarbon receptor nuclear translocator (ARNT) and transcriptional activation of several xenobiotic phase I and phase II metabolizing enzymes. It is generally accepted that the toxic responses of polycyclic aromatic hydrocarbons, dioxins, and structurally related compounds are mediated by activation of the AhR. A multitude of studies indicate that the AhR operates beyond xenobiotic metabolism and exerts pleiotropic functions. Increasing evidence points to a protective role of the AhR against carcinogenesis and oxidative stress. Herein, I will highlight data demonstrating a causal role of the AhR in the antioxidant response and present novel findings on potential AhR-mediated antioxidative mechanisms.http://dx.doi.org/10.1155/2016/7943495 |
| spellingShingle | Cornelia Dietrich Antioxidant Functions of the Aryl Hydrocarbon Receptor Stem Cells International |
| title | Antioxidant Functions of the Aryl Hydrocarbon Receptor |
| title_full | Antioxidant Functions of the Aryl Hydrocarbon Receptor |
| title_fullStr | Antioxidant Functions of the Aryl Hydrocarbon Receptor |
| title_full_unstemmed | Antioxidant Functions of the Aryl Hydrocarbon Receptor |
| title_short | Antioxidant Functions of the Aryl Hydrocarbon Receptor |
| title_sort | antioxidant functions of the aryl hydrocarbon receptor |
| url | http://dx.doi.org/10.1155/2016/7943495 |
| work_keys_str_mv | AT corneliadietrich antioxidantfunctionsofthearylhydrocarbonreceptor |