Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences
Cytotoxic interface dermatitis (CID) is a pattern reaction predominantly at the dermo-epidermal junction that encapsulates numerous chronic non-communicable inflammatory skin conditions in which the basal keratinocytes are attacked by T-cell infiltrate leading to apoptosis, lymphocytic satellitosis...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1471590/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591150564769792 |
|---|---|
| author | Shriya Kannan Neil B. Wong Grace E. Ryan Nia E. R. James Ayodeji Ajayi Janet E. Lubov Clement N. David Linda Wrijil Nicholas A. Robinson Kelly Hughes Ramon M. Almela Jillian M. Richmond |
| author_facet | Shriya Kannan Neil B. Wong Grace E. Ryan Nia E. R. James Ayodeji Ajayi Janet E. Lubov Clement N. David Linda Wrijil Nicholas A. Robinson Kelly Hughes Ramon M. Almela Jillian M. Richmond |
| author_sort | Shriya Kannan |
| collection | DOAJ |
| description | Cytotoxic interface dermatitis (CID) is a pattern reaction predominantly at the dermo-epidermal junction that encapsulates numerous chronic non-communicable inflammatory skin conditions in which the basal keratinocytes are attacked by T-cell infiltrate leading to apoptosis, lymphocytic satellitosis and vacuolar degeneration. Though many diseases include CID, the type of clinical presentation and tissue patterns expressed from disease to disease varies. In this study, we evaluate the commonalities and discrepancies in significantly expressed biomarkers across several CID conditions to examine their impact on clinical presentations in canines. Among the uniquely expressed genes in each disease, we observed significantly expressed IFNG in Discoid Lupus Erythematosus, TRAT1 in Epitheliotropic Lymphoma, and CXCL8 and CSF3R in pemphigus affected dogs. With this knowledge, we may be able to use molecular signatures in combination with current treatment practices to develop a more targeted treatment plan for patients with CID. |
| format | Article |
| id | doaj-art-1b14f176fa894fd0b6d24dc61193c018 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-1b14f176fa894fd0b6d24dc61193c0182025-01-22T16:25:27ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.14715901471590Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differencesShriya Kannan0Neil B. Wong1Grace E. Ryan2Nia E. R. James3Ayodeji Ajayi4Janet E. Lubov5Clement N. David6Linda Wrijil7Nicholas A. Robinson8Kelly Hughes9Ramon M. Almela10Jillian M. Richmond11Department of Dermatology, UMass Chan Medical School, Worcester, MA, United StatesDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, United StatesDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, United StatesDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, United StatesDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, United StatesDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, United StatesNanoString Technologies, Seattle, WA, United StatesPathology Department, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, United StatesPathology Department, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, United StatesPathology Department, Colorado State University, Fort Collins, CO, United StatesDepartment of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA, United StatesDepartment of Dermatology, UMass Chan Medical School, Worcester, MA, United StatesCytotoxic interface dermatitis (CID) is a pattern reaction predominantly at the dermo-epidermal junction that encapsulates numerous chronic non-communicable inflammatory skin conditions in which the basal keratinocytes are attacked by T-cell infiltrate leading to apoptosis, lymphocytic satellitosis and vacuolar degeneration. Though many diseases include CID, the type of clinical presentation and tissue patterns expressed from disease to disease varies. In this study, we evaluate the commonalities and discrepancies in significantly expressed biomarkers across several CID conditions to examine their impact on clinical presentations in canines. Among the uniquely expressed genes in each disease, we observed significantly expressed IFNG in Discoid Lupus Erythematosus, TRAT1 in Epitheliotropic Lymphoma, and CXCL8 and CSF3R in pemphigus affected dogs. With this knowledge, we may be able to use molecular signatures in combination with current treatment practices to develop a more targeted treatment plan for patients with CID.https://www.frontiersin.org/articles/10.3389/fvets.2024.1471590/fullcytotoxic interface dermatitis (CID)discoid lupus erythematosus (DLE)epitheliotropic lymphoma (EL)/cutaneous T cell lymphoma (CTCL)pemphiguserythema multiformeVogt–Koyanagi–Harada (VKH) |
| spellingShingle | Shriya Kannan Neil B. Wong Grace E. Ryan Nia E. R. James Ayodeji Ajayi Janet E. Lubov Clement N. David Linda Wrijil Nicholas A. Robinson Kelly Hughes Ramon M. Almela Jillian M. Richmond Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences Frontiers in Veterinary Science cytotoxic interface dermatitis (CID) discoid lupus erythematosus (DLE) epitheliotropic lymphoma (EL)/cutaneous T cell lymphoma (CTCL) pemphigus erythema multiforme Vogt–Koyanagi–Harada (VKH) |
| title | Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences |
| title_full | Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences |
| title_fullStr | Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences |
| title_full_unstemmed | Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences |
| title_short | Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences |
| title_sort | evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences |
| topic | cytotoxic interface dermatitis (CID) discoid lupus erythematosus (DLE) epitheliotropic lymphoma (EL)/cutaneous T cell lymphoma (CTCL) pemphigus erythema multiforme Vogt–Koyanagi–Harada (VKH) |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1471590/full |
| work_keys_str_mv | AT shriyakannan evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT neilbwong evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT graceeryan evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT niaerjames evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT ayodejiajayi evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT janetelubov evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT clementndavid evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT lindawrijil evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT nicholasarobinson evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT kellyhughes evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT ramonmalmela evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences AT jillianmrichmond evaluatingbiomarkersincaninecytotoxicinterfacedermatitisreactionstoaccountforclinicalandhistopathologicalsimilaritiesanddifferences |