Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children
Idiopathic nontransplant-related childhood bronchiolitis obliterans is an uncommon disease. Most patients present with chronic recurrent dyspnea, cough and wheezing, which are also features of asthma, by far a much more common condition. The present case study reports on a six-year-old girl who...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2005/413758 |
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| author | EY Chan Sharon D Dell |
| author_facet | EY Chan Sharon D Dell |
| author_sort | EY Chan |
| collection | DOAJ |
| description | Idiopathic nontransplant-related childhood bronchiolitis obliterans is an uncommon disease. Most patients present with chronic recurrent dyspnea, cough and wheezing, which are also features of asthma, by far a much more common condition. The present case study reports on a six-year-old girl who presented to a tertiary care centre with recurrent episodes of respiratory distress on a background of baseline tachypnea, chronic hypoxemia and exertional dyspnea. Her past medical history revealed significant lung disease in infancy, including respiratory syncytial virus bronchiolitis and repaired gastroesophageal reflux. She was treated for 'asthma exacerbations' throughout her early childhood years. Bronchiolitis obliterans was subsequently diagnosed with an open lung biopsy. She did not have sustained improvement with systemic corticosteroids, hydroxychloroquine or clarithromycin. Cardiac catheterization confirmed the presence of secondary pulmonary hypertension. Treatment options remain a dilemma for this patient because there is no known effective treatment for this condition, and the natural history is not well understood. The present case demonstrates the need for careful workup in 'atypical asthma', and the urgent need for further research into the rare lung diseases of childhood. |
| format | Article |
| id | doaj-art-1b0af8f8255d442e8da10284f47bfaee |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-1b0af8f8255d442e8da10284f47bfaee2025-02-03T01:26:38ZengWileyCanadian Respiratory Journal1198-22412005-01-0112631732010.1155/2005/413758Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in ChildrenEY Chan0Sharon D Dell1Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, CanadaDivision of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, CanadaIdiopathic nontransplant-related childhood bronchiolitis obliterans is an uncommon disease. Most patients present with chronic recurrent dyspnea, cough and wheezing, which are also features of asthma, by far a much more common condition. The present case study reports on a six-year-old girl who presented to a tertiary care centre with recurrent episodes of respiratory distress on a background of baseline tachypnea, chronic hypoxemia and exertional dyspnea. Her past medical history revealed significant lung disease in infancy, including respiratory syncytial virus bronchiolitis and repaired gastroesophageal reflux. She was treated for 'asthma exacerbations' throughout her early childhood years. Bronchiolitis obliterans was subsequently diagnosed with an open lung biopsy. She did not have sustained improvement with systemic corticosteroids, hydroxychloroquine or clarithromycin. Cardiac catheterization confirmed the presence of secondary pulmonary hypertension. Treatment options remain a dilemma for this patient because there is no known effective treatment for this condition, and the natural history is not well understood. The present case demonstrates the need for careful workup in 'atypical asthma', and the urgent need for further research into the rare lung diseases of childhood.http://dx.doi.org/10.1155/2005/413758 |
| spellingShingle | EY Chan Sharon D Dell Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children Canadian Respiratory Journal |
| title | Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children |
| title_full | Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children |
| title_fullStr | Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children |
| title_full_unstemmed | Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children |
| title_short | Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children |
| title_sort | pediatric interstitial lung disease masquerading as difficult asthma management dilemmas for rare lung disease in children |
| url | http://dx.doi.org/10.1155/2005/413758 |
| work_keys_str_mv | AT eychan pediatricinterstitiallungdiseasemasqueradingasdifficultasthmamanagementdilemmasforrarelungdiseaseinchildren AT sharonddell pediatricinterstitiallungdiseasemasqueradingasdifficultasthmamanagementdilemmasforrarelungdiseaseinchildren |