Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT
Purpose. To assess the macular, choroid, and peripapillary nerve fiber layer thickness (RNFL) in Behçet’s disease (BD) patients with and without ocular involvement by means of optical coherence tomography (OCT) and compare these findings with healthy controls. Design. Eighty patients with BD and 40...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/865394 |
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| author | Mustafa Ataş İsa Yuvacı Süleyman Demircan Emel Güler Orhan Altunel Emine Pangal Altan Göktaş Serap Sütbeyaz Gökmen Zararsız |
| author_facet | Mustafa Ataş İsa Yuvacı Süleyman Demircan Emel Güler Orhan Altunel Emine Pangal Altan Göktaş Serap Sütbeyaz Gökmen Zararsız |
| author_sort | Mustafa Ataş |
| collection | DOAJ |
| description | Purpose. To assess the macular, choroid, and peripapillary nerve fiber layer thickness (RNFL) in Behçet’s disease (BD) patients with and without ocular involvement by means of optical coherence tomography (OCT) and compare these findings with healthy controls.
Design. Eighty patients with BD and 40 healthy controls who were followed up at the Uveitis and Retina Clinic of the Kayseri Research and Education Hospital in Turkey were enrolled in this prospective study.
Subjects and Controls. The patients with BD were divided into two groups according to the presence of ocular involvement. Group 1 consisted of 40 eyes of 40 patients with ocular involvement and group 2 consisted of 40 eyes of 40 patients without ocular involvement.
Methods. All of the patients and controls underwent macular, choroid, and peripapillary nerve fiber layer thickness analysis with Spectralis domain OCT (Spectralis OCT Heidelberg Engineering, Dossenheim, Germany).
Main Outcome Measures. The differences in macular, choroid, and peripapillary nerve fiber layer thicknesses between groups were analyzed statistically.
Results. Macular thickness was thinner in patients with BD than in the control group; this result was statistically significant (P = 0.05). There was no statistically significant difference in thickness between RNFL analysis of the patients with BD and control subjects. However, the BD patients with ocular involvement had statistically significant thinning in RNFL compared with BD patients without ocular involvement. Although the choroid was thicker in patients with BD than in the control group, it did not reach a statistically significant level (P = 0.382).
Conclusions. BD with ocular involvement may be associated with decreased macular and RNFL thickness measured with spectral-domain OCT. |
| format | Article |
| id | doaj-art-1b0855160b9f4b588cc1ba4ef28edbc9 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-1b0855160b9f4b588cc1ba4ef28edbc92025-02-03T01:01:59ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/865394865394Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCTMustafa Ataş0İsa Yuvacı1Süleyman Demircan2Emel Güler3Orhan Altunel4Emine Pangal5Altan Göktaş6Serap Sütbeyaz7Gökmen Zararsız8Department of Ophthalmology, Kayseri Research and Teaching Hospital, Kocasinan, Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Research and Teaching Hospital, Kocasinan, Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Research and Teaching Hospital, Kocasinan, Kayseri, TurkeyDepartment of Physical Medicine and Rehabilitation, Kayseri Research and Teaching Hospital, TurkeyDepartment of Ophthalmology, Kayseri Research and Teaching Hospital, Kocasinan, Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Research and Teaching Hospital, Kocasinan, Kayseri, TurkeyDepartment of Ophthalmology, Kayseri Research and Teaching Hospital, Kocasinan, Kayseri, TurkeyDepartment of Physical Medicine and Rehabilitation, Kayseri Research and Teaching Hospital, TurkeyDepartment of Biostatistics, Medical School, University of Erciyes, TurkeyPurpose. To assess the macular, choroid, and peripapillary nerve fiber layer thickness (RNFL) in Behçet’s disease (BD) patients with and without ocular involvement by means of optical coherence tomography (OCT) and compare these findings with healthy controls. Design. Eighty patients with BD and 40 healthy controls who were followed up at the Uveitis and Retina Clinic of the Kayseri Research and Education Hospital in Turkey were enrolled in this prospective study. Subjects and Controls. The patients with BD were divided into two groups according to the presence of ocular involvement. Group 1 consisted of 40 eyes of 40 patients with ocular involvement and group 2 consisted of 40 eyes of 40 patients without ocular involvement. Methods. All of the patients and controls underwent macular, choroid, and peripapillary nerve fiber layer thickness analysis with Spectralis domain OCT (Spectralis OCT Heidelberg Engineering, Dossenheim, Germany). Main Outcome Measures. The differences in macular, choroid, and peripapillary nerve fiber layer thicknesses between groups were analyzed statistically. Results. Macular thickness was thinner in patients with BD than in the control group; this result was statistically significant (P = 0.05). There was no statistically significant difference in thickness between RNFL analysis of the patients with BD and control subjects. However, the BD patients with ocular involvement had statistically significant thinning in RNFL compared with BD patients without ocular involvement. Although the choroid was thicker in patients with BD than in the control group, it did not reach a statistically significant level (P = 0.382). Conclusions. BD with ocular involvement may be associated with decreased macular and RNFL thickness measured with spectral-domain OCT.http://dx.doi.org/10.1155/2014/865394 |
| spellingShingle | Mustafa Ataş İsa Yuvacı Süleyman Demircan Emel Güler Orhan Altunel Emine Pangal Altan Göktaş Serap Sütbeyaz Gökmen Zararsız Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT Journal of Ophthalmology |
| title | Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT |
| title_full | Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT |
| title_fullStr | Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT |
| title_full_unstemmed | Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT |
| title_short | Evaluation of the Macular, Peripapillary Nerve Fiber Layer and Choroid Thickness Changes in Behçet’s Disease with Spectral-Domain OCT |
| title_sort | evaluation of the macular peripapillary nerve fiber layer and choroid thickness changes in behcet s disease with spectral domain oct |
| url | http://dx.doi.org/10.1155/2014/865394 |
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