Loss of endothelial TRPC1 aggravates metabolic dysfunction in obesity via disrupting adipose tissue homeostasis

Loss of endothelial TRPC1 aggravates metabolic dysfunction in obesity via disrupting adipose tissue homeostasis

IntroductionWhile obesity exacerbates metabolic disorders through vascular endothelial dysfunction, the specific regulatory mechanisms of endothelial cells underlying this process remain poorly defined. Although the transient receptor potential canonical 1 (TRPC1) channel demonstrates tissue-specifi...

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Bibliographic Details
Main Authors: Yihui Lan, Shiquan Wang, Yuan Chu, Yizhi Zhang, Yuan Liu, Fan Yu, Lei Feng, Yifei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
TRPC1
endothelial cells
obesity
metabolic dysfunction
inflammation
thermogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1619559/full
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