Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort
Introduction. Patients with Parkinson’s disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates wi...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2019/2672075 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545352391065600 |
|---|---|
| author | Ashani Jeyadevan Megan C. Bakeberg Michelle Byrnes Jade Kenna Soumya Ghosh Rick Stell Sue Walters Tess Evans Sarah McGregor Malcolm Horne Frank L. Mastaglia Ryan S. Anderton |
| author_facet | Ashani Jeyadevan Megan C. Bakeberg Michelle Byrnes Jade Kenna Soumya Ghosh Rick Stell Sue Walters Tess Evans Sarah McGregor Malcolm Horne Frank L. Mastaglia Ryan S. Anderton |
| author_sort | Ashani Jeyadevan |
| collection | DOAJ |
| description | Introduction. Patients with Parkinson’s disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates with mild cognitive impairment (MCI), or is altered in a PD patient cohort with MCI. Methods. A total of 302 patients with idiopathic PD were recruited sequentially from three Australian Movement Disorder clinics. Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; n = 113) and the other with normal cognitive function (PD-C; n = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). Total impulsivity scores, as well as subscale scores, were compared between PD-C and PD-MCI groups. Results. The PD-MCI cohort had significantly lower scores in all cognitive domains, and mirrored expected clinical differences in medication, motor symptoms, and disease duration, when compared to the PD-C cohort. Self-reported impulsivity was not significantly different between groups, nor was there a difference within first-order subscale scores: attention p=0.137, cognitive instability p=0.787, self-control p=0.503, cognitive complexity p=0.157, motor impulsivity p=0.559, or perseverance p=0.734 between the PD-MCI and PD-C groups. Conclusions. These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment. |
| format | Article |
| id | doaj-art-1af43a51b9a945338fb10b83086bc55b |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-1af43a51b9a945338fb10b83086bc55b2025-02-03T07:25:55ZengWileyParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/26720752672075Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease CohortAshani Jeyadevan0Megan C. Bakeberg1Michelle Byrnes2Jade Kenna3Soumya Ghosh4Rick Stell5Sue Walters6Tess Evans7Sarah McGregor8Malcolm Horne9Frank L. Mastaglia10Ryan S. Anderton11School of Health Sciences, University of Notre Dame Australia, Fremantle, WA, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, WA, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, WA, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, WA, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, WA, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, WA, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, WA, AustraliaInstitute of Health Research, University of Notre Dame Australia, Fremantle, WA, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, AustraliaPerron Institute for Neurological and Translational Science, Nedlands, WA, AustraliaSchool of Health Sciences, University of Notre Dame Australia, Fremantle, WA, AustraliaIntroduction. Patients with Parkinson’s disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates with mild cognitive impairment (MCI), or is altered in a PD patient cohort with MCI. Methods. A total of 302 patients with idiopathic PD were recruited sequentially from three Australian Movement Disorder clinics. Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; n = 113) and the other with normal cognitive function (PD-C; n = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). Total impulsivity scores, as well as subscale scores, were compared between PD-C and PD-MCI groups. Results. The PD-MCI cohort had significantly lower scores in all cognitive domains, and mirrored expected clinical differences in medication, motor symptoms, and disease duration, when compared to the PD-C cohort. Self-reported impulsivity was not significantly different between groups, nor was there a difference within first-order subscale scores: attention p=0.137, cognitive instability p=0.787, self-control p=0.503, cognitive complexity p=0.157, motor impulsivity p=0.559, or perseverance p=0.734 between the PD-MCI and PD-C groups. Conclusions. These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment.http://dx.doi.org/10.1155/2019/2672075 |
| spellingShingle | Ashani Jeyadevan Megan C. Bakeberg Michelle Byrnes Jade Kenna Soumya Ghosh Rick Stell Sue Walters Tess Evans Sarah McGregor Malcolm Horne Frank L. Mastaglia Ryan S. Anderton Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort Parkinson's Disease |
| title | Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort |
| title_full | Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort |
| title_fullStr | Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort |
| title_full_unstemmed | Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort |
| title_short | Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort |
| title_sort | trait impulsivity is independent of mild cognitive impairment in a parkinson s disease cohort |
| url | http://dx.doi.org/10.1155/2019/2672075 |
| work_keys_str_mv | AT ashanijeyadevan traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT megancbakeberg traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT michellebyrnes traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT jadekenna traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT soumyaghosh traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT rickstell traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT suewalters traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT tessevans traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT sarahmcgregor traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT malcolmhorne traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT franklmastaglia traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort AT ryansanderton traitimpulsivityisindependentofmildcognitiveimpairmentinaparkinsonsdiseasecohort |