Inhibition of platin-induced BCL2 increase overcomes chemoresistance in squamous cell carcinoma of the head and neck through resensitization to cell death

Inhibition of platin-induced BCL2 increase overcomes chemoresistance in squamous cell carcinoma of the head and neck through resensitization to cell death

The clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor with high recurrence rates, in part due to resistance to concurrent platinum-based chemotherapy. The anti-apoptotic BCL2 protein is involved in apoptosis resistance and tumor cell invasion/migration. Here, we test whe...

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Bibliographic Details
Main Authors: Anne-Sophie Becker, Friederike Klauk, Thomas Freitag, Daniel Fabian Strüder, Björn Schneider, Annette Zimpfer, Claudia Maletzki
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Translational Oncology
Subjects:
Head and neck squamous cell carcinoma
BCL2
ABT-199
Cisplatin
Chemoresistance
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325000397
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