Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus
Medicinal plants play a fundamental part in health sectors via the management of different infectious diseases because of their wide plenitude wellspring of bioactive phytochemicals. Research activities on them have got attention throughout the world in the present days in search of low-cost and saf...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/2691525 |
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| _version_ | 1832555145483780096 |
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| author | Bikash Adhikari |
| author_facet | Bikash Adhikari |
| author_sort | Bikash Adhikari |
| collection | DOAJ |
| description | Medicinal plants play a fundamental part in health sectors via the management of different infectious diseases because of their wide plenitude wellspring of bioactive phytochemicals. Research activities on them have got attention throughout the world in the present days in search of low-cost and safe compounds for the management of diabetes. This is the literature-based analysis of alkaloids from medicinal plants in preventive or treatment approaches to diabetes. The most abundant and diversified group of secondary metabolites, i.e., alkaloids, show antidiabetic activity through the inhibition of enzymes (α-amylase, α-glucosidase, aldose reductase, dipeptidyl peptidase-IV, and protein tyrosine phosphatase-1B); inhibition of advanced glycation end products; increment of insulin secretion and its sensitivity; enhancement of glucose uptake; and their antioxidant ability. The study is useful for the examination of dynamic alkaloids for the advancement of a new medication for mankind. |
| format | Article |
| id | doaj-art-1af1b92ab8f040adb5a8c84608d5a64b |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-1af1b92ab8f040adb5a8c84608d5a64b2025-02-03T05:49:28ZengWileyJournal of Chemistry2090-90712021-01-01202110.1155/2021/2691525Roles of Alkaloids from Medicinal Plants in the Management of Diabetes MellitusBikash Adhikari0Central Department of ChemistryMedicinal plants play a fundamental part in health sectors via the management of different infectious diseases because of their wide plenitude wellspring of bioactive phytochemicals. Research activities on them have got attention throughout the world in the present days in search of low-cost and safe compounds for the management of diabetes. This is the literature-based analysis of alkaloids from medicinal plants in preventive or treatment approaches to diabetes. The most abundant and diversified group of secondary metabolites, i.e., alkaloids, show antidiabetic activity through the inhibition of enzymes (α-amylase, α-glucosidase, aldose reductase, dipeptidyl peptidase-IV, and protein tyrosine phosphatase-1B); inhibition of advanced glycation end products; increment of insulin secretion and its sensitivity; enhancement of glucose uptake; and their antioxidant ability. The study is useful for the examination of dynamic alkaloids for the advancement of a new medication for mankind.http://dx.doi.org/10.1155/2021/2691525 |
| spellingShingle | Bikash Adhikari Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus Journal of Chemistry |
| title | Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus |
| title_full | Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus |
| title_fullStr | Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus |
| title_full_unstemmed | Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus |
| title_short | Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus |
| title_sort | roles of alkaloids from medicinal plants in the management of diabetes mellitus |
| url | http://dx.doi.org/10.1155/2021/2691525 |
| work_keys_str_mv | AT bikashadhikari rolesofalkaloidsfrommedicinalplantsinthemanagementofdiabetesmellitus |