Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game
The interaction between tumor progression and innate immune system has been well established in the last years. Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis o...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/568783 |
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| author | Paqui G. Través Alfonso Luque Sonsoles Hortelano |
| author_facet | Paqui G. Través Alfonso Luque Sonsoles Hortelano |
| author_sort | Paqui G. Través |
| collection | DOAJ |
| description | The interaction between tumor progression and innate immune system has been well established in the last years. Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis of a variety of cancers. In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells.
Tumor suppressor genes have been traditionally linked to the regulation of cancer progression; however, a growing body of evidence indicates that these genes also play essential roles in the regulation of innate immunity pathways through molecular mechanisms that are still poorly understood. In this paper, we provide an overview of the immunobiology of TAMs as well as what is known about tumor suppressors in the context of immune responses. Recent advances regarding the role of the tumor suppressor ARF as a regulator of inflammation and macrophage polarization are also reviewed. |
| format | Article |
| id | doaj-art-1aebc1f96c294c2cb057461fd2e584f7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1aebc1f96c294c2cb057461fd2e584f72025-02-03T06:14:16ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/568783568783Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the GamePaqui G. Través0Alfonso Luque1Sonsoles Hortelano2Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USAInstituto Nacional de Investigación Agraria y Alimentaria (INIA), Centro de Investigación en Sanidad Animal (CISA), Ctra. de Algete a El Casar s/n, Valdeolmos, 28130 Madrid, SpainUnidad de Inflamación y Cáncer, Área de Biología Celular y Desarrollo, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera Majadahonda-Pozuelo, Km 2,200, Majadahonda, 28220 Madrid, SpainThe interaction between tumor progression and innate immune system has been well established in the last years. Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis of a variety of cancers. In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells. Tumor suppressor genes have been traditionally linked to the regulation of cancer progression; however, a growing body of evidence indicates that these genes also play essential roles in the regulation of innate immunity pathways through molecular mechanisms that are still poorly understood. In this paper, we provide an overview of the immunobiology of TAMs as well as what is known about tumor suppressors in the context of immune responses. Recent advances regarding the role of the tumor suppressor ARF as a regulator of inflammation and macrophage polarization are also reviewed.http://dx.doi.org/10.1155/2012/568783 |
| spellingShingle | Paqui G. Través Alfonso Luque Sonsoles Hortelano Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game Mediators of Inflammation |
| title | Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game |
| title_full | Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game |
| title_fullStr | Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game |
| title_full_unstemmed | Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game |
| title_short | Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game |
| title_sort | macrophages inflammation and tumor suppressors arf a new player in the game |
| url | http://dx.doi.org/10.1155/2012/568783 |
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