Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis
Therapeutic drug monitoring ensures optimal dosing while aiming to reduce toxicity. However, due to the high costs and complexity of testing, therapeutic drug monitoring is not routinely used in the treatment of individuals with active tuberculosis, despite the efficacy demonstrated in several rando...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2011/307150 |
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| _version_ | 1832546993887510528 |
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| author | Aylin Babalik Sharyn Mannix Denis Francis Dick Menzies |
| author_facet | Aylin Babalik Sharyn Mannix Denis Francis Dick Menzies |
| author_sort | Aylin Babalik |
| collection | DOAJ |
| description | Therapeutic drug monitoring ensures optimal dosing while aiming to reduce toxicity. However, due to the high costs and complexity of testing, therapeutic drug monitoring is not routinely used in the treatment of individuals with active tuberculosis, despite the efficacy demonstrated in several randomized trials. This study reviewed data spanning five years regarding the frequency of finding low drug levels in patients with tuberculosis, the dosing adjustments that were required to achieve adequate levels and the factors associated with low drug levels. |
| format | Article |
| id | doaj-art-1adea1890ff141d4b799f7ebd0fe6c64 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-1adea1890ff141d4b799f7ebd0fe6c642025-02-03T06:46:20ZengWileyCanadian Respiratory Journal1198-22412011-01-0118422522910.1155/2011/307150Therapeutic Drug Monitoring in the Treatment of Active TuberculosisAylin Babalik0Sharyn Mannix1Denis Francis2Dick Menzies3Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, CanadaMontreal Chest Institute, Montreal, Quebec, CanadaMontreal Chest Institute, Montreal, Quebec, CanadaRespiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, CanadaTherapeutic drug monitoring ensures optimal dosing while aiming to reduce toxicity. However, due to the high costs and complexity of testing, therapeutic drug monitoring is not routinely used in the treatment of individuals with active tuberculosis, despite the efficacy demonstrated in several randomized trials. This study reviewed data spanning five years regarding the frequency of finding low drug levels in patients with tuberculosis, the dosing adjustments that were required to achieve adequate levels and the factors associated with low drug levels.http://dx.doi.org/10.1155/2011/307150 |
| spellingShingle | Aylin Babalik Sharyn Mannix Denis Francis Dick Menzies Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis Canadian Respiratory Journal |
| title | Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis |
| title_full | Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis |
| title_fullStr | Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis |
| title_full_unstemmed | Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis |
| title_short | Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis |
| title_sort | therapeutic drug monitoring in the treatment of active tuberculosis |
| url | http://dx.doi.org/10.1155/2011/307150 |
| work_keys_str_mv | AT aylinbabalik therapeuticdrugmonitoringinthetreatmentofactivetuberculosis AT sharynmannix therapeuticdrugmonitoringinthetreatmentofactivetuberculosis AT denisfrancis therapeuticdrugmonitoringinthetreatmentofactivetuberculosis AT dickmenzies therapeuticdrugmonitoringinthetreatmentofactivetuberculosis |