A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies
Introduction. Tumor lysis syndrome (TLS) is a metabolic derangement that results from rapid destruction of cells. It happens frequently in cancers receiving chemotherapy, particularly hematological malignancies. It can lead to death in severe cases. Tumor lysis syndrome that leads to acute renal fai...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3740547 |
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| author | Ammar ELJack Mohamad El Abdallah Kadhim Al-Banaa Kashif Chaudhry Faisal Musa |
| author_facet | Ammar ELJack Mohamad El Abdallah Kadhim Al-Banaa Kashif Chaudhry Faisal Musa |
| author_sort | Ammar ELJack |
| collection | DOAJ |
| description | Introduction. Tumor lysis syndrome (TLS) is a metabolic derangement that results from rapid destruction of cells. It happens frequently in cancers receiving chemotherapy, particularly hematological malignancies. It can lead to death in severe cases. Tumor lysis syndrome that leads to acute renal failure requiring dialysis and/or ICU admission can be associated with a higher rate of complications and mortality. Case Report. We present a 24-year-old male patient with Burkitt’s lymphoma. After receiving one cycle therapy, he developed severe kidney injury from TLS. We initiated renal replacement therapy soon after his admission to the ICU, with marked response to therapy. This led to early discharge from the ICU. Conclusion. Early initiation of renal replacement therapy after TLS-AKI can improve the severity of AKI and hasten recovery and prevent complications. This can lead to earlier discharge from the hospital and better outcomes. |
| format | Article |
| id | doaj-art-1adc92012a234ded82dd811d0b554362 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-1adc92012a234ded82dd811d0b5543622025-02-03T01:10:57ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/37405473740547A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological MalignanciesAmmar ELJack0Mohamad El Abdallah1Kadhim Al-Banaa2Kashif Chaudhry3Faisal Musa4Department of Internal Medicine, Beaumont Hospital-Dearborn, 18101 Oakwood, Dearborn, MI 48124, USADepartment of Internal Medicine, Beaumont Hospital-Dearborn, 18101 Oakwood, Dearborn, MI 48124, USADepartment of Internal Medicine, Beaumont Hospital-Dearborn, 18101 Oakwood, Dearborn, MI 48124, USADepartment of Nephrology, Beaumont Hospital-Dearborn, Dearborn, MI, USADepartment of Hematology and Oncology, Beaumont Hospital-Dearborn, Dearborn, MI, USAIntroduction. Tumor lysis syndrome (TLS) is a metabolic derangement that results from rapid destruction of cells. It happens frequently in cancers receiving chemotherapy, particularly hematological malignancies. It can lead to death in severe cases. Tumor lysis syndrome that leads to acute renal failure requiring dialysis and/or ICU admission can be associated with a higher rate of complications and mortality. Case Report. We present a 24-year-old male patient with Burkitt’s lymphoma. After receiving one cycle therapy, he developed severe kidney injury from TLS. We initiated renal replacement therapy soon after his admission to the ICU, with marked response to therapy. This led to early discharge from the ICU. Conclusion. Early initiation of renal replacement therapy after TLS-AKI can improve the severity of AKI and hasten recovery and prevent complications. This can lead to earlier discharge from the hospital and better outcomes.http://dx.doi.org/10.1155/2019/3740547 |
| spellingShingle | Ammar ELJack Mohamad El Abdallah Kadhim Al-Banaa Kashif Chaudhry Faisal Musa A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies Case Reports in Oncological Medicine |
| title | A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies |
| title_full | A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies |
| title_fullStr | A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies |
| title_full_unstemmed | A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies |
| title_short | A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies |
| title_sort | new challenging strategy in the prevention and management of tumor lysis syndrome in patients with chemo sensitive hematological malignancies |
| url | http://dx.doi.org/10.1155/2019/3740547 |
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