Nasal food challenge with hen's egg white allergen
Abstract Background Nasal allergen provocation tests are an important part of the diagnostics of allergic diseases triggered by environmental factors. Recently, increased attention has been paid to the potential use of this method in the diagnosis of food allergy. The objective of the study was to e...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13223-024-00945-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594602337501184 |
|---|---|
| author | Edyta Krzych-Fałta Andrzej Namysłowski Sławomir Białek Monika E. Czerwińska Konrad Furmańczyk Aleksandra Tylewicz Adam Sybilski Bolesław Samoliński Oksana Wojas |
| author_facet | Edyta Krzych-Fałta Andrzej Namysłowski Sławomir Białek Monika E. Czerwińska Konrad Furmańczyk Aleksandra Tylewicz Adam Sybilski Bolesław Samoliński Oksana Wojas |
| author_sort | Edyta Krzych-Fałta |
| collection | DOAJ |
| description | Abstract Background Nasal allergen provocation tests are an important part of the diagnostics of allergic diseases triggered by environmental factors. Recently, increased attention has been paid to the potential use of this method in the diagnosis of food allergy. The objective of the study was to evaluate the usefulness of the nasal allergen provocation test in a group of subjects allergic to hen's egg white allergens. Methods The material consisted of a group of 57 subjects (32 subjects with hen's egg white allergy and 25 healthy controls). The method consisted in a nasal allergen provocation test carried out with the use of hen's egg white allergen and assessed using the visual analog scale and optical rhinometry as well as by determination of sIgE and tryptase levels in nasal lavage fluid. Results Subjective nasal symptoms and objective evaluations following the application of 100 µg of hen's egg white allergen revealed a moderately positive nasal mucosal response in optical rhinometry tests (ΔE = 0.34 OD). Conclusions Nasal food challenge with hen's egg white allergen is a good diagnostic alternative in the group of food allergy patients. Due to the insufficient number of studies carried out so far, further attempts at standardization of the method are required. |
| format | Article |
| id | doaj-art-1adbcb58fbf04382b4d1cb8124f3e961 |
| institution | Kabale University |
| issn | 1710-1492 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj-art-1adbcb58fbf04382b4d1cb8124f3e9612025-01-19T12:27:18ZengBMCAllergy, Asthma & Clinical Immunology1710-14922025-01-0121111010.1186/s13223-024-00945-0Nasal food challenge with hen's egg white allergenEdyta Krzych-Fałta0Andrzej Namysłowski1Sławomir Białek2Monika E. Czerwińska3Konrad Furmańczyk4Aleksandra Tylewicz5Adam Sybilski6Bolesław Samoliński7Oksana Wojas8Department of Basic Nursing, Medical University of WarsawDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of WarsawDepartment of Biochemistry and Pharmacogenomics, Medical University of WarsawDepartment of Biochemistry and Pharmacogenomics, Medical University of WarsawInstitute of Information Technology, Warsaw University of Life SciencesSecond Department of Pediatrics, Centre of Postgraduate Medical EducationSecond Department of Pediatrics, Centre of Postgraduate Medical EducationDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of WarsawDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of WarsawAbstract Background Nasal allergen provocation tests are an important part of the diagnostics of allergic diseases triggered by environmental factors. Recently, increased attention has been paid to the potential use of this method in the diagnosis of food allergy. The objective of the study was to evaluate the usefulness of the nasal allergen provocation test in a group of subjects allergic to hen's egg white allergens. Methods The material consisted of a group of 57 subjects (32 subjects with hen's egg white allergy and 25 healthy controls). The method consisted in a nasal allergen provocation test carried out with the use of hen's egg white allergen and assessed using the visual analog scale and optical rhinometry as well as by determination of sIgE and tryptase levels in nasal lavage fluid. Results Subjective nasal symptoms and objective evaluations following the application of 100 µg of hen's egg white allergen revealed a moderately positive nasal mucosal response in optical rhinometry tests (ΔE = 0.34 OD). Conclusions Nasal food challenge with hen's egg white allergen is a good diagnostic alternative in the group of food allergy patients. Due to the insufficient number of studies carried out so far, further attempts at standardization of the method are required.https://doi.org/10.1186/s13223-024-00945-0Food allergyNasal allergen challengeNasal food challenge |
| spellingShingle | Edyta Krzych-Fałta Andrzej Namysłowski Sławomir Białek Monika E. Czerwińska Konrad Furmańczyk Aleksandra Tylewicz Adam Sybilski Bolesław Samoliński Oksana Wojas Nasal food challenge with hen's egg white allergen Allergy, Asthma & Clinical Immunology Food allergy Nasal allergen challenge Nasal food challenge |
| title | Nasal food challenge with hen's egg white allergen |
| title_full | Nasal food challenge with hen's egg white allergen |
| title_fullStr | Nasal food challenge with hen's egg white allergen |
| title_full_unstemmed | Nasal food challenge with hen's egg white allergen |
| title_short | Nasal food challenge with hen's egg white allergen |
| title_sort | nasal food challenge with hen s egg white allergen |
| topic | Food allergy Nasal allergen challenge Nasal food challenge |
| url | https://doi.org/10.1186/s13223-024-00945-0 |
| work_keys_str_mv | AT edytakrzychfałta nasalfoodchallengewithhenseggwhiteallergen AT andrzejnamysłowski nasalfoodchallengewithhenseggwhiteallergen AT sławomirbiałek nasalfoodchallengewithhenseggwhiteallergen AT monikaeczerwinska nasalfoodchallengewithhenseggwhiteallergen AT konradfurmanczyk nasalfoodchallengewithhenseggwhiteallergen AT aleksandratylewicz nasalfoodchallengewithhenseggwhiteallergen AT adamsybilski nasalfoodchallengewithhenseggwhiteallergen AT bolesławsamolinski nasalfoodchallengewithhenseggwhiteallergen AT oksanawojas nasalfoodchallengewithhenseggwhiteallergen |