Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity
Long considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520600834704 |
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| _version_ | 1832562929392680960 |
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| author | Alice Li Okechukwu Ojogho Alan Escher |
| author_facet | Alice Li Okechukwu Ojogho Alan Escher |
| author_sort | Alice Li |
| collection | DOAJ |
| description | Long considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity of APCs like macrophages and DCs to induce and maintain tolerance after phagocytosis of dead cells. Processing of apoptotic cells by DCs is of particular interest, because DCs are the only known APCs capable of activating naïve T lymphocytes to become effector or regulatory cells. In that regard, recent evidence suggests that phagocytosis of apoptotic cells by DCs can induce Tregs, a finding that has significant implications for the treatment of a variety of immune-mediated inflammatory disorders. Here, we review the relationship between apoptotic cells, DCs, and Tregs, and its impact on prevention of transplant rejection and treatment of autoimmune diseases. |
| format | Article |
| id | doaj-art-1ad691ac99f748e088e358e8d46ee4cb |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-1ad691ac99f748e088e358e8d46ee4cb2025-02-03T01:21:20ZengWileyClinical and Developmental Immunology1740-25221740-25302006-01-01132-427328210.1080/17402520600834704Saving Death: Apoptosis for Intervention in Transplantation and AutoimmunityAlice Li0Okechukwu Ojogho1Alan Escher2Center for Transplant Immunology Research, Loma Linda University & Medical Center, Loma Linda 92354, CA, USACenter for Transplant Immunology Research, Loma Linda University & Medical Center, Loma Linda 92354, CA, USACenter for Transplant Immunology Research, Loma Linda University & Medical Center, Loma Linda 92354, CA, USALong considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity of APCs like macrophages and DCs to induce and maintain tolerance after phagocytosis of dead cells. Processing of apoptotic cells by DCs is of particular interest, because DCs are the only known APCs capable of activating naïve T lymphocytes to become effector or regulatory cells. In that regard, recent evidence suggests that phagocytosis of apoptotic cells by DCs can induce Tregs, a finding that has significant implications for the treatment of a variety of immune-mediated inflammatory disorders. Here, we review the relationship between apoptotic cells, DCs, and Tregs, and its impact on prevention of transplant rejection and treatment of autoimmune diseases.http://dx.doi.org/10.1080/17402520600834704 |
| spellingShingle | Alice Li Okechukwu Ojogho Alan Escher Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity Clinical and Developmental Immunology |
| title | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
| title_full | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
| title_fullStr | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
| title_full_unstemmed | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
| title_short | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
| title_sort | saving death apoptosis for intervention in transplantation and autoimmunity |
| url | http://dx.doi.org/10.1080/17402520600834704 |
| work_keys_str_mv | AT aliceli savingdeathapoptosisforinterventionintransplantationandautoimmunity AT okechukwuojogho savingdeathapoptosisforinterventionintransplantationandautoimmunity AT alanescher savingdeathapoptosisforinterventionintransplantationandautoimmunity |