Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation
Proinflammatory CD4+ T cells without the costimulatory molecule CD28 (CD4+CD28null T cells) are expanded in patients with end-stage renal disease (ESRD) and associated with atherosclerotic vascular events (AVE). In a prospective study, the number of circulating CD4+CD28null T cells was established i...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2013/841430 |
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| author | Michiel G. H. Betjes Willem Weimar Nicolle H. R. Litjens |
| author_facet | Michiel G. H. Betjes Willem Weimar Nicolle H. R. Litjens |
| author_sort | Michiel G. H. Betjes |
| collection | DOAJ |
| description | Proinflammatory CD4+ T cells without the costimulatory molecule CD28 (CD4+CD28null T cells) are expanded in patients with end-stage renal disease (ESRD) and associated with atherosclerotic vascular events (AVE). In a prospective study, the number of circulating CD4+CD28null T cells was established in 295 ESRD patients prior to receiving a kidney allograft. Within the first year after transplantation, an AVE occurred in 20 patients. Univariate analysis showed that besides a history of cardiovascular disease (CVDpos, HR 8.1, ), age (HR 1.04, ), dyslipidaemia (HR 8.8, ), and the % of CD4+CD28null T cells (HR 1.04 per % increase, 95% CI 1.00–1.09, ) were significantly associated with the occurrence of a posttransplantation AVE. In a multivariate analysis, only CVDpos remained a significant risk factor with a significant and positive interaction between the terms CVDpos and the % of CD4+CD28null T cells (HR 1.05, 95% CI 1.03–1.11, ). Within the CVDpos group, the incidence of an AVE was 13% in the lowest tertile compared to 25% in the highest tertile of % of CD4+CD28null T cells. In conclusion, the presence of circulating CD4+CD28null T cells is associated with an increased risk for a cardiovascular event shortly after kidney transplantation. |
| format | Article |
| id | doaj-art-1ad5772be47b4e228f0574957ca82b04 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-1ad5772be47b4e228f0574957ca82b042025-02-03T05:46:43ZengWileyJournal of Transplantation2090-00072090-00152013-01-01201310.1155/2013/841430841430Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney TransplantationMichiel G. H. Betjes0Willem Weimar1Nicolle H. R. Litjens2Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology & Transplantation, D414, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsErasmus Medical Center, Department of Internal Medicine, Division of Nephrology & Transplantation, D414, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsErasmus Medical Center, Department of Internal Medicine, Division of Nephrology & Transplantation, D414, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsProinflammatory CD4+ T cells without the costimulatory molecule CD28 (CD4+CD28null T cells) are expanded in patients with end-stage renal disease (ESRD) and associated with atherosclerotic vascular events (AVE). In a prospective study, the number of circulating CD4+CD28null T cells was established in 295 ESRD patients prior to receiving a kidney allograft. Within the first year after transplantation, an AVE occurred in 20 patients. Univariate analysis showed that besides a history of cardiovascular disease (CVDpos, HR 8.1, ), age (HR 1.04, ), dyslipidaemia (HR 8.8, ), and the % of CD4+CD28null T cells (HR 1.04 per % increase, 95% CI 1.00–1.09, ) were significantly associated with the occurrence of a posttransplantation AVE. In a multivariate analysis, only CVDpos remained a significant risk factor with a significant and positive interaction between the terms CVDpos and the % of CD4+CD28null T cells (HR 1.05, 95% CI 1.03–1.11, ). Within the CVDpos group, the incidence of an AVE was 13% in the lowest tertile compared to 25% in the highest tertile of % of CD4+CD28null T cells. In conclusion, the presence of circulating CD4+CD28null T cells is associated with an increased risk for a cardiovascular event shortly after kidney transplantation.http://dx.doi.org/10.1155/2013/841430 |
| spellingShingle | Michiel G. H. Betjes Willem Weimar Nicolle H. R. Litjens Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation Journal of Transplantation |
| title | Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation |
| title_full | Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation |
| title_fullStr | Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation |
| title_full_unstemmed | Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation |
| title_short | Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation |
| title_sort | circulating cd4 cd28null t cells may increase the risk of an atherosclerotic vascular event shortly after kidney transplantation |
| url | http://dx.doi.org/10.1155/2013/841430 |
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