A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients
Abstract Background: The present research examines the part interleukin-17 (IL-17) plays in the progression of liver disease in people infected with the long-term hepatitis B virus. A proinflammatory cytokine called IL-17, linked to a number of autoimmune disorders, was examined in serum samples tak...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_996_23 |
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| author | Noor R. Abady Zeana Shakir Al-Al Hindi |
| author_facet | Noor R. Abady Zeana Shakir Al-Al Hindi |
| author_sort | Noor R. Abady |
| collection | DOAJ |
| description | Abstract Background: The present research examines the part interleukin-17 (IL-17) plays in the progression of liver disease in people infected with the long-term hepatitis B virus. A proinflammatory cytokine called IL-17, linked to a number of autoimmune disorders, was examined in serum samples taken from different participant groups. Objective: The aim of this study is to examine the levels of IL-17 in various participant groups and understand any possible influence on the development and course of liver fibrosis. Materials and Methods: There were four groups in the study: asymptomatic HBsAg carriers (n = 42), chronic hepatitis B (CHB, n = 57), liver cirrhosis (LC, n = 59), and the normal control group (n = 80). an Enzyme-Linked was used to measure the amounts of IL-17, while reverse transcription polymerase chain reaction was used to find IL-17 mRNA in peripheral blood mononuclear cells (PBMC). Results: Liver disorders such as cirrhosis and CHB are associated with elevated levels of IL-17. Both the subjects’ serum and PBMCs showed these elevated IL-17 levels, demonstrating a strong correlation with inflammation. These findings highlight the significant function of IL-17 in the possible management or treatment of a variety of liver-related conditions. Conclusion: The investigation comes to the conclusion that IL-17 levels increase as liver disease severity increases, suggesting that it is involved in the development of fibrosis and the progression of the disease. Gaining insight into the function of IL-17 may help develop more effective therapies for CHB and LC patients. It is crucial to conduct further research in this area to develop tailored therapeutics. |
| format | Article |
| id | doaj-art-1acc8d2df58b4d518b02f9ee7debe362 |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-1acc8d2df58b4d518b02f9ee7debe3622025-01-25T10:14:50ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-01-0121119119410.4103/MJBL.MJBL_996_23A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus PatientsNoor R. AbadyZeana Shakir Al-Al HindiAbstract Background: The present research examines the part interleukin-17 (IL-17) plays in the progression of liver disease in people infected with the long-term hepatitis B virus. A proinflammatory cytokine called IL-17, linked to a number of autoimmune disorders, was examined in serum samples taken from different participant groups. Objective: The aim of this study is to examine the levels of IL-17 in various participant groups and understand any possible influence on the development and course of liver fibrosis. Materials and Methods: There were four groups in the study: asymptomatic HBsAg carriers (n = 42), chronic hepatitis B (CHB, n = 57), liver cirrhosis (LC, n = 59), and the normal control group (n = 80). an Enzyme-Linked was used to measure the amounts of IL-17, while reverse transcription polymerase chain reaction was used to find IL-17 mRNA in peripheral blood mononuclear cells (PBMC). Results: Liver disorders such as cirrhosis and CHB are associated with elevated levels of IL-17. Both the subjects’ serum and PBMCs showed these elevated IL-17 levels, demonstrating a strong correlation with inflammation. These findings highlight the significant function of IL-17 in the possible management or treatment of a variety of liver-related conditions. Conclusion: The investigation comes to the conclusion that IL-17 levels increase as liver disease severity increases, suggesting that it is involved in the development of fibrosis and the progression of the disease. Gaining insight into the function of IL-17 may help develop more effective therapies for CHB and LC patients. It is crucial to conduct further research in this area to develop tailored therapeutics.https://doi.org/10.4103/MJBL.MJBL_996_23chronic hepatitis bil17 expressionil17 rna (mrna)liver cirrhosis |
| spellingShingle | Noor R. Abady Zeana Shakir Al-Al Hindi A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients Medical Journal of Babylon chronic hepatitis b il 17 expression il 17 rna (mrna) liver cirrhosis |
| title | A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients |
| title_full | A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients |
| title_fullStr | A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients |
| title_full_unstemmed | A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients |
| title_short | A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients |
| title_sort | cytokine that is involved in immune responses in chronic hepatitis b virus patients |
| topic | chronic hepatitis b il 17 expression il 17 rna (mrna) liver cirrhosis |
| url | https://doi.org/10.4103/MJBL.MJBL_996_23 |
| work_keys_str_mv | AT noorrabady acytokinethatisinvolvedinimmuneresponsesinchronichepatitisbviruspatients AT zeanashakiralalhindi acytokinethatisinvolvedinimmuneresponsesinchronichepatitisbviruspatients AT noorrabady cytokinethatisinvolvedinimmuneresponsesinchronichepatitisbviruspatients AT zeanashakiralalhindi cytokinethatisinvolvedinimmuneresponsesinchronichepatitisbviruspatients |