Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis
Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region of IL-6 gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/621893 |
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| author | Svetla Nikolova Milka Dikova Dobrin Dikov Assen Djerov Gyulnas Dzhebir Ventseslav Atanasov Alexey Savov Ivo Kremensky |
| author_facet | Svetla Nikolova Milka Dikova Dobrin Dikov Assen Djerov Gyulnas Dzhebir Ventseslav Atanasov Alexey Savov Ivo Kremensky |
| author_sort | Svetla Nikolova |
| collection | DOAJ |
| description | Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region of IL-6 gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to investigate the association between IS and the IL-6 promoter polymorphism at -174 position (rs1800795 G/C) in Bulgarian population. Molecular detection of the IL-6 genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson’s chi-squared test. Our case-control study revealed a statistically significant association between the IL-6 (-174 G/C) functional polymorphism and susceptibility to IS. In addition, a significant association between the IL-6 (-174 G/C) polymorphism and curve severity was detected. IL-6 gene could be considered as susceptibility and modifying factor of idiopathic scoliosis. The identification of molecular markers with diagnostic and prognostic value could be useful for early detection of children at risk for the development of scoliosis and for prognosis of the risk for a rapid deformity progression. That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures. |
| format | Article |
| id | doaj-art-1ac60d4abc074ad5b477291cbaa2167f |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-1ac60d4abc074ad5b477291cbaa2167f2025-02-03T05:48:00ZengWileyAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/621893621893Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic ScoliosisSvetla Nikolova0Milka Dikova1Dobrin Dikov2Assen Djerov3Gyulnas Dzhebir4Ventseslav Atanasov5Alexey Savov6Ivo Kremensky7National Genetic Laboratory, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaUniversity Orthopedic Hospital “Prof. Boycho Boychev”, 56 Nikola Petkov Boulevard, 1614 Sofia, BulgariaUniversity Orthopedic Hospital “Prof. Boycho Boychev”, 56 Nikola Petkov Boulevard, 1614 Sofia, BulgariaUniversity Orthopedic Hospital “Prof. Boycho Boychev”, 56 Nikola Petkov Boulevard, 1614 Sofia, BulgariaMolecular Medicine Center, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaNational Genetic Laboratory, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaNational Genetic Laboratory, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaMolecular Medicine Center, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, BulgariaScoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region of IL-6 gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to investigate the association between IS and the IL-6 promoter polymorphism at -174 position (rs1800795 G/C) in Bulgarian population. Molecular detection of the IL-6 genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson’s chi-squared test. Our case-control study revealed a statistically significant association between the IL-6 (-174 G/C) functional polymorphism and susceptibility to IS. In addition, a significant association between the IL-6 (-174 G/C) polymorphism and curve severity was detected. IL-6 gene could be considered as susceptibility and modifying factor of idiopathic scoliosis. The identification of molecular markers with diagnostic and prognostic value could be useful for early detection of children at risk for the development of scoliosis and for prognosis of the risk for a rapid deformity progression. That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures.http://dx.doi.org/10.1155/2015/621893 |
| spellingShingle | Svetla Nikolova Milka Dikova Dobrin Dikov Assen Djerov Gyulnas Dzhebir Ventseslav Atanasov Alexey Savov Ivo Kremensky Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis Analytical Cellular Pathology |
| title | Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis |
| title_full | Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis |
| title_fullStr | Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis |
| title_full_unstemmed | Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis |
| title_short | Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis |
| title_sort | role of the il 6 gene in the etiopathogenesis of idiopathic scoliosis |
| url | http://dx.doi.org/10.1155/2015/621893 |
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