High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus
High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined t...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/3671892 |
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| author | Yoshiichi Takagi Taichi Sugimoto Masaya Kobayashi Mitsuyuki Shirai Fumitoshi Asai |
| author_facet | Yoshiichi Takagi Taichi Sugimoto Masaya Kobayashi Mitsuyuki Shirai Fumitoshi Asai |
| author_sort | Yoshiichi Takagi |
| collection | DOAJ |
| description | High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks. Systolic blood pressure and urine volume were increased in WBKDF-HS and Wistar-HS. Body weight gain and food consumption were comparable between NS and HS in both strains. Plasma and urine glucose levels were significantly increased in WBKDF-NS but not in WBKDF-HS. HOMA-IR in WBKDF-HS was significantly lower compared with that in WBKDF-NS. The high plasma adiponectin level in WBKDF-NS compared with that in Wistar-NS was further enhanced in WBKDF-HS. Glycogen deposits and fat droplets in the livers of WBKDF-HS were reduced compared with those of WBKDF-NS. The present study demonstrated that HS intake ameliorated hyperglycemia and insulin resistance in WBKDF rats, which may be due to increased plasma levels of adiponectin. |
| format | Article |
| id | doaj-art-1ac50a8193b541ac9c6ec01c8ef36818 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1ac50a8193b541ac9c6ec01c8ef368182025-02-03T01:20:59ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/36718923671892High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes MellitusYoshiichi Takagi0Taichi Sugimoto1Masaya Kobayashi2Mitsuyuki Shirai3Fumitoshi Asai4Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, JapanHigh-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks. Systolic blood pressure and urine volume were increased in WBKDF-HS and Wistar-HS. Body weight gain and food consumption were comparable between NS and HS in both strains. Plasma and urine glucose levels were significantly increased in WBKDF-NS but not in WBKDF-HS. HOMA-IR in WBKDF-HS was significantly lower compared with that in WBKDF-NS. The high plasma adiponectin level in WBKDF-NS compared with that in Wistar-NS was further enhanced in WBKDF-HS. Glycogen deposits and fat droplets in the livers of WBKDF-HS were reduced compared with those of WBKDF-NS. The present study demonstrated that HS intake ameliorated hyperglycemia and insulin resistance in WBKDF rats, which may be due to increased plasma levels of adiponectin.http://dx.doi.org/10.1155/2018/3671892 |
| spellingShingle | Yoshiichi Takagi Taichi Sugimoto Masaya Kobayashi Mitsuyuki Shirai Fumitoshi Asai High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus Journal of Diabetes Research |
| title | High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus |
| title_full | High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus |
| title_fullStr | High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus |
| title_full_unstemmed | High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus |
| title_short | High-Salt Intake Ameliorates Hyperglycemia and Insulin Resistance in WBN/Kob-Leprfa/fa Rats: A New Model of Type 2 Diabetes Mellitus |
| title_sort | high salt intake ameliorates hyperglycemia and insulin resistance in wbn kob leprfa fa rats a new model of type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2018/3671892 |
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