Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study
Abstract Background This study aimed to assess the prognosis of T1-2N0 stage tongue cancer patients who underwent surgery for the primary lesion without elective neck dissection and to identify the risk factors for prognosis. Methods We retrospectively analyzed early-stage tongue cancer patients in...
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BMC
2025-03-01
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| Online Access: | https://doi.org/10.1186/s12903-025-05694-z |
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| author | Guanzheng Chen Xiangpan Kong Zhien Feng Jia Kang Zhengxue Han Bo Li |
| author_facet | Guanzheng Chen Xiangpan Kong Zhien Feng Jia Kang Zhengxue Han Bo Li |
| author_sort | Guanzheng Chen |
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| description | Abstract Background This study aimed to assess the prognosis of T1-2N0 stage tongue cancer patients who underwent surgery for the primary lesion without elective neck dissection and to identify the risk factors for prognosis. Methods We retrospectively analyzed early-stage tongue cancer patients in our center. Statistical analyses were performed using SPSS and R software. Results The study reviewed 168 patients, revealing a 3-year overall survival rate of 90.5%, a 3-year cervical lymph node metastasis-free survival rate of 73.2%, and a 3-year disease-specific survival rate of 89.3%. A depth of invasion of 3 mm showed significant prognostic value for overall survival (P = 0.001), cervical lymph node metastasis-free survival (P = 0.002), and disease-specific survival (P < 0.001). Patients were categorized into four subgroups (thick T1, thin T1, thick T2, and thin T2) to further explore the prognostic significance of depth of invasion across different T stage categories. The combination of T stage and a 3 mm depth of invasion demonstrated significant prognostic value in univariate analysis for overall survival (P = 0.002), cervical lymph node metastasis-free survival (P = 0.010), and disease-specific survival (P < 0.001). COX regression analysis confirmed the statistical significance of T stage combined with a 3 mm depth of invasion for overall survival (OR = 10.653; 95% CI, 2.394 to 47.404; P = 0.002) and lymph node metastasis-free survival (OR = 3.016; 95% CI, 1.365 to 6.667; P = 0.006). Conclusions The findings highlight depth of invasion and T stage as key prognostic factors in early-stage tongue squamous cell carcinoma. Consideration of elective neck dissection is advised for patients with T2 tumors and a depth of invasion exceeding 3 mm to potentially enhance their prognosis. Trial registration The current research was registered in Chinese Clinical Trial Registry on April 8, 2021. The trial registration number is ChiCTR2100045188. |
| format | Article |
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| institution | DOAJ |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| series | BMC Oral Health |
| spelling | doaj-art-1ac26b0c4ca043f9ae3e7e214faa3d2c2025-08-20T02:56:20ZengBMCBMC Oral Health1472-68312025-03-012511810.1186/s12903-025-05694-zNecessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort studyGuanzheng Chen0Xiangpan Kong1Zhien Feng2Jia Kang3Zhengxue Han4Bo Li5Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical UniversityAbstract Background This study aimed to assess the prognosis of T1-2N0 stage tongue cancer patients who underwent surgery for the primary lesion without elective neck dissection and to identify the risk factors for prognosis. Methods We retrospectively analyzed early-stage tongue cancer patients in our center. Statistical analyses were performed using SPSS and R software. Results The study reviewed 168 patients, revealing a 3-year overall survival rate of 90.5%, a 3-year cervical lymph node metastasis-free survival rate of 73.2%, and a 3-year disease-specific survival rate of 89.3%. A depth of invasion of 3 mm showed significant prognostic value for overall survival (P = 0.001), cervical lymph node metastasis-free survival (P = 0.002), and disease-specific survival (P < 0.001). Patients were categorized into four subgroups (thick T1, thin T1, thick T2, and thin T2) to further explore the prognostic significance of depth of invasion across different T stage categories. The combination of T stage and a 3 mm depth of invasion demonstrated significant prognostic value in univariate analysis for overall survival (P = 0.002), cervical lymph node metastasis-free survival (P = 0.010), and disease-specific survival (P < 0.001). COX regression analysis confirmed the statistical significance of T stage combined with a 3 mm depth of invasion for overall survival (OR = 10.653; 95% CI, 2.394 to 47.404; P = 0.002) and lymph node metastasis-free survival (OR = 3.016; 95% CI, 1.365 to 6.667; P = 0.006). Conclusions The findings highlight depth of invasion and T stage as key prognostic factors in early-stage tongue squamous cell carcinoma. Consideration of elective neck dissection is advised for patients with T2 tumors and a depth of invasion exceeding 3 mm to potentially enhance their prognosis. Trial registration The current research was registered in Chinese Clinical Trial Registry on April 8, 2021. The trial registration number is ChiCTR2100045188.https://doi.org/10.1186/s12903-025-05694-zTongue squamous cell carcinomaCervical lymph node metastasisElective neck dissectionOverall survivalDisease specific survival |
| spellingShingle | Guanzheng Chen Xiangpan Kong Zhien Feng Jia Kang Zhengxue Han Bo Li Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study BMC Oral Health Tongue squamous cell carcinoma Cervical lymph node metastasis Elective neck dissection Overall survival Disease specific survival |
| title | Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study |
| title_full | Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study |
| title_fullStr | Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study |
| title_full_unstemmed | Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study |
| title_short | Necessity of selective neck dissection for T1-2N0 TSCC patients: a retrospective cohort study |
| title_sort | necessity of selective neck dissection for t1 2n0 tscc patients a retrospective cohort study |
| topic | Tongue squamous cell carcinoma Cervical lymph node metastasis Elective neck dissection Overall survival Disease specific survival |
| url | https://doi.org/10.1186/s12903-025-05694-z |
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