Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential
Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are pre...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24005280 |
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| author | Wenhan Tian Yuzeng Liu Bo Han Fengqi Cheng Kang Yang Weiyuan Hu Dongdong Ye Sujun Wu Jiping Yang Qi Chen Yong Hai Robert O. Ritchie Guanping He Juan Guan |
| author_facet | Wenhan Tian Yuzeng Liu Bo Han Fengqi Cheng Kang Yang Weiyuan Hu Dongdong Ye Sujun Wu Jiping Yang Qi Chen Yong Hai Robert O. Ritchie Guanping He Juan Guan |
| author_sort | Wenhan Tian |
| collection | DOAJ |
| description | Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are prepared to mimic the hierarchical structure of natural bones, through the inheritance of the hierarchical structure of fiber silk and the integration with a polyester matrix. Due to the robust interface between the matrix and fiber silk, CFSCs show maintained stable long-term mechanical performance under wet conditions. During in vivo degradation, this material primarily undergoes host cell-mediated surface degradation, rather than bulk hydrolysis. We demonstrate significant capabilities of CFSCs in promoting vascularization and macrophage differentiation toward repair. A bone defect model further indicates the potential of CFSC for bone graft applications. Our belief is that the material family of CFSCs may promise a novel biomaterial strategy for yet to be achieved excellent regenerative implants. |
| format | Article |
| id | doaj-art-1ac017c838ec41c88f40b9af154cfe59 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-1ac017c838ec41c88f40b9af154cfe592025-01-26T05:04:26ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145584598Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potentialWenhan Tian0Yuzeng Liu1Bo Han2Fengqi Cheng3Kang Yang4Weiyuan Hu5Dongdong Ye6Sujun Wu7Jiping Yang8Qi Chen9Yong Hai10Robert O. Ritchie11Guanping He12Juan Guan13School of Materials Science and Engineering, Beihang University, Beijing, 100191, PR ChinaDepartment of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, PR China; Corresponding author.Department of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, PR ChinaDepartment of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, PR ChinaSchool of Materials Science and Engineering, Anhui University of Technology, Maanshan, Anhui, 243002, PR ChinaSchool of Materials Science and Engineering, Beihang University, Beijing, 100191, PR ChinaCollege of Light Textile Engineering and Art, Anhui Agricultural University, Hefei, Anhui, 230036, PR ChinaSchool of Materials Science and Engineering, Beihang University, Beijing, 100191, PR ChinaSchool of Materials Science and Engineering, Beihang University, Beijing, 100191, PR ChinaNingbo Regen Biotech Co., Ltd., Ningbo, Zhejiang, 315157, PR ChinaDepartment of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, PR ChinaDepartment of Materials Science & Engineering, University of California, Berkeley, CA, 94720, USA; Corresponding author.Department of Orthopedics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, PR China; Corresponding author.School of Materials Science and Engineering, Beihang University, Beijing, 100191, PR China; Beijing Advanced Innovation Center for Biomedical Engineering, Beijing, 100083, PR China; Corresponding author. School of Materials Science and Engineering, Beihang University, Beijing, 100191, PR China.Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are prepared to mimic the hierarchical structure of natural bones, through the inheritance of the hierarchical structure of fiber silk and the integration with a polyester matrix. Due to the robust interface between the matrix and fiber silk, CFSCs show maintained stable long-term mechanical performance under wet conditions. During in vivo degradation, this material primarily undergoes host cell-mediated surface degradation, rather than bulk hydrolysis. We demonstrate significant capabilities of CFSCs in promoting vascularization and macrophage differentiation toward repair. A bone defect model further indicates the potential of CFSC for bone graft applications. Our belief is that the material family of CFSCs may promise a novel biomaterial strategy for yet to be achieved excellent regenerative implants.http://www.sciencedirect.com/science/article/pii/S2452199X24005280Hierarchical structureContinuous fiber silkRegenerative biomaterialCell-mediated degradationMacrophage polarization |
| spellingShingle | Wenhan Tian Yuzeng Liu Bo Han Fengqi Cheng Kang Yang Weiyuan Hu Dongdong Ye Sujun Wu Jiping Yang Qi Chen Yong Hai Robert O. Ritchie Guanping He Juan Guan Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential Bioactive Materials Hierarchical structure Continuous fiber silk Regenerative biomaterial Cell-mediated degradation Macrophage polarization |
| title | Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential |
| title_full | Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential |
| title_fullStr | Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential |
| title_full_unstemmed | Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential |
| title_short | Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential |
| title_sort | mechanically robust surface degradable implant from fiber silk composites demonstrates regenerative potential |
| topic | Hierarchical structure Continuous fiber silk Regenerative biomaterial Cell-mediated degradation Macrophage polarization |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24005280 |
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