Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing
The purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and w...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/790234 |
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| _version_ | 1832567289552044032 |
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| author | Latha Satish Sandeep Kathju |
| author_facet | Latha Satish Sandeep Kathju |
| author_sort | Latha Satish |
| collection | DOAJ |
| description | The purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar formation. In contrast, fetal wound repair occurs with minimal inflammation, faster re-epithelialization, and without the accumulation of scar. Although research into scarless healing began decades ago, the critical molecular mechanisms driving the process of regenerative fetal healing remain uncertain. Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring. |
| format | Article |
| id | doaj-art-1abe851161904bdbb2f08b4d5740393c |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-1abe851161904bdbb2f08b4d5740393c2025-02-03T01:01:48ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/790234790234Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound HealingLatha Satish0Sandeep Kathju1Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USACenter for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USAThe purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar formation. In contrast, fetal wound repair occurs with minimal inflammation, faster re-epithelialization, and without the accumulation of scar. Although research into scarless healing began decades ago, the critical molecular mechanisms driving the process of regenerative fetal healing remain uncertain. Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring.http://dx.doi.org/10.1155/2010/790234 |
| spellingShingle | Latha Satish Sandeep Kathju Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing Dermatology Research and Practice |
| title | Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing |
| title_full | Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing |
| title_fullStr | Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing |
| title_full_unstemmed | Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing |
| title_short | Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing |
| title_sort | cellular and molecular characteristics of scarless versus fibrotic wound healing |
| url | http://dx.doi.org/10.1155/2010/790234 |
| work_keys_str_mv | AT lathasatish cellularandmolecularcharacteristicsofscarlessversusfibroticwoundhealing AT sandeepkathju cellularandmolecularcharacteristicsofscarlessversusfibroticwoundhealing |