Effect of Ananas comosus methanol leaf extract on immature, non-pregnant and pregnant uterus of adult female albino wistar rat
Background: The leaves of Ananas comosus is used traditionally as an abortifacient among the Indians. Objective(s): The objective of this study is to investigate the anti-conceptive and anti-implantation, estrogenic and anti-estrogenic effect of Ananas comosus methanol leaf extract on a uterus o...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nigerian Medical Association, Akwa Ibom State Branch
2025-04-01
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| Series: | Ibom Medical Journal |
| Subjects: | |
| Online Access: | http://ibommedicaljournal.org/index.php/imjhome/article/view/671 |
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| Summary: | Background: The leaves of Ananas comosus is used traditionally as an abortifacient among the Indians.
Objective(s): The objective of this study is to investigate the anti-conceptive and anti-implantation, estrogenic and anti-estrogenic effect of Ananas comosus methanol leaf extract on a uterus of female albino Wistar rat.
Study Design: Mature female wistar rats with regular consecutive oestrus cycle were divided into 5 groups of 5 animals each. The experimental groups received 485.5 mg/kg, 970 mg/kg and 1455.5 mg/kg body weight respectively with the control group receiving 1 ml/rat/day body weight of normal saline. Mating was done before and after administration of the extract for the anti-conceptive and anti-implantation experiments respectively. The antiestrogenic and estrogenic effect was done in immature ovariectomized rats using 17β estradiol as reference while the experimental groups were given same dose as above.
Result: Pregnancy was significantly prevented in a dose dependent manner as the low dose group had a reduced number of pups littered while the medium and high dose groups had no litters. The medium and high dose groups had no implantation sites. There was a very weak estrogenic but strong anti-estrogenic effect of the extract.
Conclusion: The study showed that A. comosus leaf extract prevented conception in rats through its anti-implantation and anti-oestrogenic effects.
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| ISSN: | 1597-7188 2735-9964 |