A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression
nc886 (=vtRNA2-1, pre-miR-886, or CBL3) is a newly identified non-coding RNA (ncRNA) that represses the activity of protein kinase R (PKR). nc886 is transcribed by RNA polymerase III (Pol III) and is intriguingly the first case of a Pol III gene whose expression is silenced by CpG DNA hypermethylati...
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BioMed Central
2015-06-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-13-26.pdf |
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| author | Yong Sun Lee |
| author_facet | Yong Sun Lee |
| author_sort | Yong Sun Lee |
| collection | DOAJ |
| description | nc886 (=vtRNA2-1, pre-miR-886, or CBL3) is a newly identified non-coding RNA (ncRNA) that represses the activity of protein kinase R (PKR). nc886 is transcribed by RNA polymerase III (Pol III) and is intriguingly the first case of a Pol III gene whose expression is silenced by CpG DNA hypermethylation in several types of cancer. PKR is a sensor protein that recognizes evading viruses and induces apoptosis to eliminate infected cells. Like viral infection, nc886 silencing activates PKR and induces apoptosis. Thus, the significance of the nc886:PKR pathway in cancer is to sense and eliminate pre-malignant cells, which is analogous to PKR's role in cellular innate immunity. Beyond this tumor sensing role, nc886 plays a putative tumor suppressor role as supported by experimental evidence. Collectively, nc886 provides a novel example how epigenetic silencing of a ncRNA contributes to tumorigenesis by controlling the activity of its protein ligand. |
| format | Article |
| id | doaj-art-1ab63c7bf76244dd91ec89daf1f9bcd4 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-1ab63c7bf76244dd91ec89daf1f9bcd42025-02-02T09:41:31ZengBioMed CentralGenomics & Informatics1598-866X2234-07422015-06-01132263010.5808/GI.2015.13.2.26149A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and SuppressionYong Sun Lee0Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.nc886 (=vtRNA2-1, pre-miR-886, or CBL3) is a newly identified non-coding RNA (ncRNA) that represses the activity of protein kinase R (PKR). nc886 is transcribed by RNA polymerase III (Pol III) and is intriguingly the first case of a Pol III gene whose expression is silenced by CpG DNA hypermethylation in several types of cancer. PKR is a sensor protein that recognizes evading viruses and induces apoptosis to eliminate infected cells. Like viral infection, nc886 silencing activates PKR and induces apoptosis. Thus, the significance of the nc886:PKR pathway in cancer is to sense and eliminate pre-malignant cells, which is analogous to PKR's role in cellular innate immunity. Beyond this tumor sensing role, nc886 plays a putative tumor suppressor role as supported by experimental evidence. Collectively, nc886 provides a novel example how epigenetic silencing of a ncRNA contributes to tumorigenesis by controlling the activity of its protein ligand.http://genominfo.org/upload/pdf/gni-13-26.pdfnc886non-coding RNAPKRtumor suppressortumor surveillance |
| spellingShingle | Yong Sun Lee A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression Genomics & Informatics nc886 non-coding RNA PKR tumor suppressor tumor surveillance |
| title | A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression |
| title_full | A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression |
| title_fullStr | A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression |
| title_full_unstemmed | A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression |
| title_short | A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression |
| title_sort | novel type of non coding rna nc886 implicated in tumor sensing and suppression |
| topic | nc886 non-coding RNA PKR tumor suppressor tumor surveillance |
| url | http://genominfo.org/upload/pdf/gni-13-26.pdf |
| work_keys_str_mv | AT yongsunlee anoveltypeofnoncodingrnanc886implicatedintumorsensingandsuppression AT yongsunlee noveltypeofnoncodingrnanc886implicatedintumorsensingandsuppression |