Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases
The increased global incidence of chronic metabolic diseases, a vital threat to human health and a burden on our healthcare systems, includes a series of clinical metabolic syndromes such as obesity, diabetes, hypertension, and dyslipidemia. One of the well-known probiotic microorganisms, Lactiplant...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2023-07-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002373 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544037252366336 |
|---|---|
| author | Lei Tian Ruixiang Zhao Xinyi Xu Zhiwei Zhou Xiaofang Xu Dongmei Luo Zhiqiang Zhou Yu Liu Ariel Kushmaro Robert S. Marks András Dinnyés Qun Sun |
| author_facet | Lei Tian Ruixiang Zhao Xinyi Xu Zhiwei Zhou Xiaofang Xu Dongmei Luo Zhiqiang Zhou Yu Liu Ariel Kushmaro Robert S. Marks András Dinnyés Qun Sun |
| author_sort | Lei Tian |
| collection | DOAJ |
| description | The increased global incidence of chronic metabolic diseases, a vital threat to human health and a burden on our healthcare systems, includes a series of clinical metabolic syndromes such as obesity, diabetes, hypertension, and dyslipidemia. One of the well-known probiotic microorganisms, Lactiplantibacillus plantarum plays an important role in promoting human health, including inhibiting the occurrence and development of a variety of chronic metabolic diseases. The present study provides an overview of the preventive and therapeutic effects of L. plantarum on diabetes, obesity, non-alcoholic fatty liver disease, kidney stone disease, and cardiovascular diseases in animal models and human clinical trials. Ingesting L. plantarum demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids (SCFAs), the activity of antioxidant enzymes, and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic diseases. Furthermore, updated applications and technologies of L. plantarum in food and biopharmaceutical industries are also discussed. Understanding the characteristics and functions of L. plantarum will guide the development of related probiotic products and explore the modulatory benefit of L. plantarum supplementations on the prevention and treatment of multiple chronic metabolic diseases. |
| format | Article |
| id | doaj-art-1a911984ef454e329cf12bd70cb39d3f |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-1a911984ef454e329cf12bd70cb39d3f2025-02-03T11:09:29ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-01124959974Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseasesLei Tian0Ruixiang Zhao1Xinyi Xu2Zhiwei Zhou3Xiaofang Xu4Dongmei Luo5Zhiqiang Zhou6Yu Liu7Ariel Kushmaro8Robert S. Marks9András Dinnyés10Qun Sun11Key Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, ChinaInstitute for Marine and Antarctic Studies, University of Tasmania, Newnham 7248, AustraliaKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, ChinaKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, ChinaKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, ChinaKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, ChinaCollege of Biomass Science and Engineering, Sichuan University, Chengdu 610064, ChinaDepartment of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, ChinaAvram and Stella Goldstein-Goren, Department of Biotechnology Engineering, Faculty of Engineering Sciences, Ben Gurion University of the Negev, Beer-Sheva 84105, IsraelAvram and Stella Goldstein-Goren, Department of Biotechnology Engineering, Faculty of Engineering Sciences, Ben Gurion University of the Negev, Beer-Sheva 84105, IsraelKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China; BioTalentum Ltd., Gödöllő 2100, Hungary; Department of Cell Biology and Molecular Medicine, University of Szeged, Szeged H-6270, Hungary; Hungarian University of Agriculture and Life Sciences, Institute of Physiology and Animal Nutrition, Department of Physiology and Animal Health, Gödöllő 2100, HungaryKey Laboratory of Bio-Resource and Eco-Environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China; College of Biomass Science and Engineering, Sichuan University, Chengdu 610064, China; Corresponding author at: College of Life Sciences, Sichuan University, Chengdu 610064, China.The increased global incidence of chronic metabolic diseases, a vital threat to human health and a burden on our healthcare systems, includes a series of clinical metabolic syndromes such as obesity, diabetes, hypertension, and dyslipidemia. One of the well-known probiotic microorganisms, Lactiplantibacillus plantarum plays an important role in promoting human health, including inhibiting the occurrence and development of a variety of chronic metabolic diseases. The present study provides an overview of the preventive and therapeutic effects of L. plantarum on diabetes, obesity, non-alcoholic fatty liver disease, kidney stone disease, and cardiovascular diseases in animal models and human clinical trials. Ingesting L. plantarum demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids (SCFAs), the activity of antioxidant enzymes, and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic diseases. Furthermore, updated applications and technologies of L. plantarum in food and biopharmaceutical industries are also discussed. Understanding the characteristics and functions of L. plantarum will guide the development of related probiotic products and explore the modulatory benefit of L. plantarum supplementations on the prevention and treatment of multiple chronic metabolic diseases.http://www.sciencedirect.com/science/article/pii/S2213453022002373Lactiplantibacillus plantarumDiabetesObesityNon-alcoholic fatty liver diseaseKidney stone diseaseCardiovascular diseases |
| spellingShingle | Lei Tian Ruixiang Zhao Xinyi Xu Zhiwei Zhou Xiaofang Xu Dongmei Luo Zhiqiang Zhou Yu Liu Ariel Kushmaro Robert S. Marks András Dinnyés Qun Sun Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases Food Science and Human Wellness Lactiplantibacillus plantarum Diabetes Obesity Non-alcoholic fatty liver disease Kidney stone disease Cardiovascular diseases |
| title | Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases |
| title_full | Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases |
| title_fullStr | Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases |
| title_full_unstemmed | Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases |
| title_short | Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases |
| title_sort | modulatory effects of lactiplantibacillus plantarum on chronic metabolic diseases |
| topic | Lactiplantibacillus plantarum Diabetes Obesity Non-alcoholic fatty liver disease Kidney stone disease Cardiovascular diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002373 |
| work_keys_str_mv | AT leitian modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT ruixiangzhao modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT xinyixu modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT zhiweizhou modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT xiaofangxu modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT dongmeiluo modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT zhiqiangzhou modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT yuliu modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT arielkushmaro modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT robertsmarks modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT andrasdinnyes modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases AT qunsun modulatoryeffectsoflactiplantibacillusplantarumonchronicmetabolicdiseases |